Mitchell, Ian John, Cooper, A. J., Brown, G. D. A. (Gordon D. A.) and Waters, C. M.. (1995) Apoptosis of the neurons in the vestibular nucleus of the adult mouse is induced by prolonged rotation of the home cage. The Journal of Physiology, Vol.483 . P34-P35. ISSN 0022-3751

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Abstract

Pharmacological manipulations which result in abnormal levels of excitatory amino acid (EAA) mediated neurotransmission can result in neuronal apoptosis. We accordingly hypothesised that manipulations of the external environment which induce prolonged EAA-mediated transmission in sensory neurons may also induce apoptosis. This hypothesis was tested by placing groups of adult mice, housed in their home cage, on a turntable which slowly rotated (0.8 rev./min). This non-invasive manipulation will have resulted in abnormal discharge patterns in the vestibular nuclei. Significantly greater levels of neuronal apoptosis were seen in the vestibular complex after rotation for 48 h compared with non-rotated controls. This finding was also predicted independently from a computational approach.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Q Science > QP Physiology
Divisions:	Faculty of Science > Psychology
Library of Congress Subject Headings (LCSH):	Apoptosis, Neurons, Vestibular nuclei, Mice -- Physiology, Animal cages -- Experiments, Sensorimotor integration
Journal or Publication Title:	The Journal of Physiology
Publisher:	Wiley-Blackwell Publishing Ltd.
ISSN:	0022-3751
Date:	February 1995
Volume:	Vol.483
Number of Pages:	2
Page Range:	P34-P35
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Conference Paper Type:	Paper
Type of Event:	Conference
URI:	http://wrap.warwick.ac.uk/id/eprint/19939

Data sourced from Thomson Reuters' Web of Knowledge

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