Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

IDENTIFIABILITY AND INDISTINGUISHABILITY OF NONLINEAR PHARMACOKINETIC MODELS

Tools
- Tools
+ Tools

UNSPECIFIED (1994) IDENTIFIABILITY AND INDISTINGUISHABILITY OF NONLINEAR PHARMACOKINETIC MODELS. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 22 (3). pp. 229-251.

Research output not available from this repository, contact author.

Request Changes to record.

Abstract

Three nonlinear model structures of interest in pharmacokinetics are analyzed to determine whether the unknown, independent, model parameters can be deduced if perfect input-output data were available. This is the problem of identifiability. The method used is based on the local state isomorphism theorem. In certain circumstances, the modeler may be undecided between several model structures and it is then of interest to determine whether different model structures can be distinguished from perfect input-output data. This is the problem of model indistinguishability. The technique used, again based on the local state isomorphism theorem, parallels the similarity transformation approach for linear systems described previously in this journal. The analysis is performed on three two-compartment examples having one linear and one nonlinear (Michaelis-Menten) elimination pathway. In each model there is, on physiological and other grounds, some uncertainty over the precise location (central compartment or peripheral compartment) of one of the elimination pathways.

Item Type: Journal Article
Subjects: R Medicine > RS Pharmacy and materia medica
Journal or Publication Title: JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS
Publisher: PLENUM PUBL CORP
ISSN: 0090-466X
Official Date: June 1994
Dates:
DateEvent
June 1994UNSPECIFIED
Volume: 22
Number: 3
Number of Pages: 23
Page Range: pp. 229-251
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us