UNSPECIFIED (1994) OXIDATIVE MUTAGENS INDUCE INTRACHROMOSOMAL RECOMBINATION IN YEAST. MUTATION RESEARCH, 308 (2). pp. 159-167. ISSN 0921-8262

Full text not available from this repository.

Abstract

Active oxygen species are thought to be involved in the causation of a number of diseases including cancers. We have investigated the effect of 5 oxidative mutagens, methyl viologen (paraquat), mitomycin C, phenylhydrazine, cumene hydroperoxide and hydrogen peroxide, on the frequency of both intrachromosomal recombination and interchromosomal recombination in the yeast Saccharomyces cerevisiae. All of the chemicals significantly increased the frequency of intrachromosomal recombination in a dose-dependent manner. Only hydrogen peroxide increased the frequency of interchromosomal recombination at the doses tested in this study. A role for hydroxyl radical (OH) in the effect of H2O2 on recombination is indicated by the ability of the radical scavenger dimethyl sulfoxide (DMSO) to significantly inhibit the induction of both intrachromosomal and interchromosomal recombination by H2O2. The results presented here give further support for the suitability of intrachromosomal recombination measurements as a short-term test for the detection of mutagens and carcinogens.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RA Public aspects of medicine
Journal or Publication Title:	MUTATION RESEARCH
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0921-8262
Date:	16 July 1994
Volume:	308
Number:	2
Number of Pages:	9
Page Range:	pp. 159-167
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/20534

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item