UNSPECIFIED. (1994) ANTIGENIC DIVERSITY OF RESPIRATORY SYNCYTIAL VIRUS SUBGROUP-B STRAINS CIRCULATING DURING A COMMUNITY OUTBREAK OF INFECTION. JOURNAL OF MEDICAL VIROLOGY, 42 (4). pp. 380-384. ISSN 0146-6615

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Abstract

The epidemiological characteristics and relationship between respiratory syncytial virus (RSV) subgroup and virulence during an outbreak of RSV infection occurring in Southeast Texas in the winter season 1991/92 are described. Fifty-two infants and children were diagnosed with RSV infection by rapid viral antigen detection and/or viral isolation. Subgrouping of the isolates was carried out using 11-monoclonal antibodies. Ten isolates were found to be subgroup B, and 8 isolates were subgroup A. The subgroup B strains showed 3 different patterns of reaction with monoclonal antibodies; one of these subgroups was examined further by restriction analysis of parts of its nucleocapsid and attachment protein genes. The peak of RSV outbreak was in December 1991. Both subtypes A and B circulated simultaneously in the same territory, and caused lower respiratory tract infections in similar proportions. The more frequent occurrence of the B subgroup and the diversity of its simultaneously circulated RSV strains have made this outbreak unusual. (C) 1994 Wiley-Liss, Inc.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF MEDICAL VIROLOGY
Publisher:	WILEY-LISS
ISSN:	0146-6615
Official Date:	April 1994
Dates:	Date Event April 1994 UNSPECIFIED
Volume:	42
Number:	4
Number of Pages:	5
Page Range:	pp. 380-384
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/20755

Data sourced from Thomson Reuters' Web of Knowledge

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