UNSPECIFIED. (1993) MODELING CIRCADIAN VARIATION IN THE PHARMACOKINETICS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 45 (4). pp. 357-361. ISSN 0031-6970

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Abstract

A one-compartment model with first-order absorption has provided, good fits to five sets of indomethacin data and four sets of ketoprofen data taken at different times of day. There was substantial variation in the model parameters with time of administration and most of the features of this variation applied equally to both drugs. From the data examined, the source of variation appears to be mainly in the absorption phase and this was confirmed using a chronokinetic analysis, in which simultaneous fits were obtained with time-variant rate parameters. However, there may also be circadian variation in protein binding. The danger of quoting parameter values for either of these two drugs based on administration at a single time of day has been illustrated, and this may well be true for other drugs.

Item Type:	Journal Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Journal or Publication Title:	EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Publisher:	SPRINGER VERLAG
ISSN:	0031-6970
Date:	November 1993
Volume:	45
Number:	4
Number of Pages:	5
Page Range:	pp. 357-361
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/20858

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