UNSPECIFIED. (1994) ANALYSIS OF PYRIDINOLINE AND ITS DERIVATIVES BY SCANNING-ARRAY 4-SECTOR TANDEM MASS-SPECTROMETRY. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 8 (1). pp. 99-104. ISSN 0951-4198

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Abstract

Structures of the trifunctional crosslink molecules, pyridinoline, deoxypyridinoline and glucosylgalactosyl-pyridinoline, have been characterized by positive-ion liquid secondary-ion mass spectrometry (LSIMS) and collision-induced dissociation with scanning-array four-sector tandem mass spectrometry. It has been found that: (i) the naturally occurring cations (Cat+) are readily desorbed by positive-ion LSIMS utilizing glycerol + thioglycerol (1:1) as liquid matrix and dominate the spectra, facilitating accurate mass measurement; (ii) changing the matrix to 3-nitrobenzyl alcohol leaves little evidence of the cation, and (iii) collision-induced dissociation of the cations (Cat+) of pyridinoline, deoxypyridinoline and glucosylgalactosyl-pyridinoline gives a wealth of fragmentation for structure elucidation. These fundamental studies of tandem mass spectra of the known trifunctional crosslink molecules provided valuable structure-related information, which help in the identification of the tissue-specific peptides containing these crosslinks. Artefact ions in these tandem mass spectra are remarkably abundant.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QC Physics
Journal or Publication Title:	RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Publisher:	JOHN WILEY & SONS LTD
ISSN:	0951-4198
Date:	January 1994
Volume:	8
Number:	1
Number of Pages:	6
Page Range:	pp. 99-104
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/20868

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