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THE BIOSYNTHESIS OF 1-DEOXYNOJIRIMYCIN IN BACILLUS-SUBTILIS VAR NIGER
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UNSPECIFIED (1993) THE BIOSYNTHESIS OF 1-DEOXYNOJIRIMYCIN IN BACILLUS-SUBTILIS VAR NIGER. TETRAHEDRON, 49 (30). pp. 6707-6716. ISSN 0040-4020.
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Abstract
Bacillus subtilis var niger ATCC 9372 when grown on a glucose containing soyabean medium produces the amino-sugar 1-deoxynojirimycin (DNJ). The C2 epimer 1-deoxy-mannojirimycin (DMJ) present in Streptomyces subrutilus ATCC 27467 is absent. C-13 and H-2 labelling studies confirm that glucose is the precursor of DNJ. Randomisation of the C-13 label from 1-[C-13]-D-glucose and the incorporation of 1-[C-13]-D,L-glyceraldehyde into DNJ also suggest that a minor part of the biosynthetic route involves cleavage of the glucose skeleton. Mannojirimycin (MJ) and nojirimycin (NJ) are postulated intermediates in the biosynthesis as a result of both enzyme assay and isotope labelling studies.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | TETRAHEDRON | ||||
Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | ||||
ISSN: | 0040-4020 | ||||
Official Date: | 23 July 1993 | ||||
Dates: |
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Volume: | 49 | ||||
Number: | 30 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 6707-6716 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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