UNSPECIFIED (1993) THE BIOSYNTHESIS OF 1-DEOXYNOJIRIMYCIN IN BACILLUS-SUBTILIS VAR NIGER. TETRAHEDRON, 49 (30). pp. 6707-6716. ISSN 0040-4020

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Abstract

Bacillus subtilis var niger ATCC 9372 when grown on a glucose containing soyabean medium produces the amino-sugar 1-deoxynojirimycin (DNJ). The C2 epimer 1-deoxy-mannojirimycin (DMJ) present in Streptomyces subrutilus ATCC 27467 is absent. C-13 and H-2 labelling studies confirm that glucose is the precursor of DNJ. Randomisation of the C-13 label from 1-[C-13]-D-glucose and the incorporation of 1-[C-13]-D,L-glyceraldehyde into DNJ also suggest that a minor part of the biosynthetic route involves cleavage of the glucose skeleton. Mannojirimycin (MJ) and nojirimycin (NJ) are postulated intermediates in the biosynthesis as a result of both enzyme assay and isotope labelling studies.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	TETRAHEDRON
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
ISSN:	0040-4020
Date:	23 July 1993
Volume:	49
Number:	30
Number of Pages:	10
Page Range:	pp. 6707-6716
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/21169

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