A MONOCLONAL-ANTIBODY PRODUCED DURING INFECTION WHICH RECOGNIZES AN EPITOPE OF INFLUENZA HEMAGGLUTININ ONLY IN THE CONTEXT OF H-2(K) MHC CLASS-I ANTIGEN
UNSPECIFIED. (1993) A MONOCLONAL-ANTIBODY PRODUCED DURING INFECTION WHICH RECOGNIZES AN EPITOPE OF INFLUENZA HEMAGGLUTININ ONLY IN THE CONTEXT OF H-2(K) MHC CLASS-I ANTIGEN. JOURNAL OF IMMUNOLOGY, 150 (8 Part 1). pp. 3421-3426. ISSN 0022-1767Full text not available from this repository.
A hybridoma prepared from cells isolated from the lungs of H-2k mice infected with influenza virus (A/WSN) produces a monoclonal IgM (LM41) which recognizes an epitope of the A/WSN hemagglutinin (HA) Ag only when it is expressed in H-2k cells, as shown by Ag binding and complement-mediated lysis. However, it did not bind to the native HA of virus particles or any form of HA protein present on A/WSN-infected H-2d cells. LM41 inhibited Ag-specific, MHC class I-restricted lysis of H-2k target cells infected with a vaccinia recombinant virus expressing the HA of A/WSN by CTL from A/WSN virus-infected H-2k mice. We conclude that LM41 has a similar Ag specificity to the HA-specific TCR.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology|
|Journal or Publication Title:||JOURNAL OF IMMUNOLOGY|
|Publisher:||AMER ASSOC IMMUNOLOGISTS|
|Official Date:||15 April 1993|
|Number:||8 Part 1|
|Number of Pages:||6|
|Page Range:||pp. 3421-3426|
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