Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

AUTOREGULATION OF CARBAPENEM BIOSYNTHESIS IN ERWINIA-CAROTOVORA BY ANALOGS OF N-(3-OXOHEXANOYL)-L-HOMOSERINE LACTONE

Tools
- Tools
+ Tools

UNSPECIFIED (1993) AUTOREGULATION OF CARBAPENEM BIOSYNTHESIS IN ERWINIA-CAROTOVORA BY ANALOGS OF N-(3-OXOHEXANOYL)-L-HOMOSERINE LACTONE. JOURNAL OF ANTIBIOTICS, 46 (3). pp. 441-454.

Research output not available from this repository, contact author.

Request Changes to record.

Abstract

N-(3-Oxohexanoyl)-L-homoserine lactone (HSL) (I) is the autoregulator controlling carbapenem antibiotic biosynthesis in Erwinia carotovora ATCC 39048. The chemical synthesis and biological evaluation of analogues of HSL are described. These include alterations of chirality, side-chain modifications, ring size and ring hetero atom. A number of compounds are reported which are capable of restoring the phenotype to a HSL negative mutant but at higher concentrations than HSL.

A-factor, the autoregulator of streptomycin biosynthesis in Streptomyces griseus, was not active as an inducer of carbapenem biosynthesis in E. carotovora.

Item Type: Journal Article
Subjects: T Technology > TP Chemical technology
Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology
R Medicine > RS Pharmacy and materia medica
Journal or Publication Title: JOURNAL OF ANTIBIOTICS
Publisher: JAPAN ANTIBIOT RES ASSN
ISSN: 0021-8820
Official Date: March 1993
Dates:
DateEvent
March 1993UNSPECIFIED
Volume: 46
Number: 3
Number of Pages: 14
Page Range: pp. 441-454
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us