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AUTOREGULATION OF CARBAPENEM BIOSYNTHESIS IN ERWINIA-CAROTOVORA BY ANALOGS OF N-(3-OXOHEXANOYL)-L-HOMOSERINE LACTONE
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UNSPECIFIED (1993) AUTOREGULATION OF CARBAPENEM BIOSYNTHESIS IN ERWINIA-CAROTOVORA BY ANALOGS OF N-(3-OXOHEXANOYL)-L-HOMOSERINE LACTONE. JOURNAL OF ANTIBIOTICS, 46 (3). pp. 441-454.
Research output not available from this repository, contact author.Abstract
N-(3-Oxohexanoyl)-L-homoserine lactone (HSL) (I) is the autoregulator controlling carbapenem antibiotic biosynthesis in Erwinia carotovora ATCC 39048. The chemical synthesis and biological evaluation of analogues of HSL are described. These include alterations of chirality, side-chain modifications, ring size and ring hetero atom. A number of compounds are reported which are capable of restoring the phenotype to a HSL negative mutant but at higher concentrations than HSL.
A-factor, the autoregulator of streptomycin biosynthesis in Streptomyces griseus, was not active as an inducer of carbapenem biosynthesis in E. carotovora.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | T Technology > TP Chemical technology Q Science > QR Microbiology > QR180 Immunology Q Science > QR Microbiology R Medicine > RS Pharmacy and materia medica |
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| Journal or Publication Title: | JOURNAL OF ANTIBIOTICS | ||||
| Publisher: | JAPAN ANTIBIOT RES ASSN | ||||
| ISSN: | 0021-8820 | ||||
| Official Date: | March 1993 | ||||
| Dates: |
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| Volume: | 46 | ||||
| Number: | 3 | ||||
| Number of Pages: | 14 | ||||
| Page Range: | pp. 441-454 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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