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DNA loci cross-talk through thermodynamics
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Scialdone, Antonio and Nicodemi, Mario (2009) DNA loci cross-talk through thermodynamics. Journal of Biomedicine and Biotechnology, 20 . 516723. doi:10.1155/2009/516723
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Official URL: http://dx.doi.org/10.1155/2009/516723
Abstract
The recognition and pairing of specific DNA loci, though crucial for a plenty of important cellular processes, are produced by still mysterious physical mechanisms. We propose the first quantitative model from Statistical Mechanics, able to clarify the interaction allowing such “DNA cross-talk” events. Soluble molecules, which bind some DNA recognition sequences, produce an effective attraction between distant DNA loci; if their affinity, their concentration, and the relative DNA binding sites number exceed given thresholds, DNA colocalization occurs as a result of a thermodynamic phase transition. In this paper, after a concise report on some of the most recent experimental results, we introduce our model and carry out a detailed “in silico” analysis of it, by means of Monte Carlo simulations. Our studies, while rationalize several experimental observations, result in very interesting and testable predictions.
Item Type: | Journal Item | ||||
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Subjects: | Q Science > QC Physics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
Library of Congress Subject Headings (LCSH): | DNA -- Research, Thermodynamics -- Research, Phase transformations (Statistical physics), Statistical mechanics | ||||
Journal or Publication Title: | Journal of Biomedicine and Biotechnology | ||||
Publisher: | Hindawi Publishing Corp. | ||||
ISSN: | 1110-7243 | ||||
Official Date: | 8 July 2009 | ||||
Dates: |
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Volume: | 20 | ||||
Article Number: | 516723 | ||||
DOI: | 10.1155/2009/516723 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | CINECA, Istituto Nazionale Fisica della Materia (INFM) |
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