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FREQUENT POLYMERASE ERRORS OBSERVED IN A RESTRICTED AREA OF CLONES DERIVED FROM THE ATTACHMENT (G) PROTEIN GENE OF RESPIRATORY SYNCYTIAL VIRUS
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UNSPECIFIED (1993) FREQUENT POLYMERASE ERRORS OBSERVED IN A RESTRICTED AREA OF CLONES DERIVED FROM THE ATTACHMENT (G) PROTEIN GENE OF RESPIRATORY SYNCYTIAL VIRUS. JOURNAL OF VIROLOGY, 67 (2). pp. 1090-1093.
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Abstract
Sequence analysis of a large number of clones derived from the carboxy-terminal one-third of the attachment (G) protein gene of subgroup A respiratory syncytial viruses revealed a region very prone to polymerase errors which resulted mainly in frameshifts because of the insertion or deletion of adenosine residues in some but not all runs of such residues. Such mutations were detected in 14% of clones derived from mRNA, 58% of clones derived from genomic-sense RNA, and 50% of clones derived from in vitro-transcribed RNA. This phenomenon appears to be dependent on the template sequence.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR355 Virology | ||||
| Journal or Publication Title: | JOURNAL OF VIROLOGY | ||||
| Publisher: | AMER SOC MICROBIOLOGY | ||||
| ISSN: | 0022-538X | ||||
| Official Date: | February 1993 | ||||
| Dates: |
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| Volume: | 67 | ||||
| Number: | 2 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 1090-1093 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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