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THE ENZYMATIC-SYNTHESIS AND ANTI-HIV ACTIVITY OF 9-BETA-D-2'-DEOXY AND 9-BETA-D-2',3'-DIDEOXYNUCLEOSIDES OF 2-AMINOPURINE
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UNSPECIFIED (1992) THE ENZYMATIC-SYNTHESIS AND ANTI-HIV ACTIVITY OF 9-BETA-D-2'-DEOXY AND 9-BETA-D-2',3'-DIDEOXYNUCLEOSIDES OF 2-AMINOPURINE. ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 3 (3). pp. 153-156.
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Abstract
The 9-beta-D-2'-deoxy and 9-beta-D-2',3'-dideoxyribonucleosides of 2-aminopurine have been prepared using crude nucleoside N-deoxyribosyltransferases (E.C. 2.4.2.6) from Lactobacillus leichmannii in the presence of 10% ethylene glycol to inhibit degradation of the product nucleosides. The 2',3'-dideoxynucleoside of 2-aminopurine is an inhibitor of the replication of HIV-1, HIV-2, and SIV with EC50 values in the range 8-100-mu-M depending on the cell line used and has low in vitro toxicity at its effective concentrations.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica Q Science > QR Microbiology > QR355 Virology |
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| Journal or Publication Title: | ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | ||||
| Publisher: | BLACKWELL SCIENCE LTD | ||||
| ISSN: | 0956-3202 | ||||
| Official Date: | 1992 | ||||
| Dates: |
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| Volume: | 3 | ||||
| Number: | 3 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 153-156 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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