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THE ENZYMATIC-SYNTHESIS AND ANTI-HIV ACTIVITY OF 9-BETA-D-2'-DEOXY AND 9-BETA-D-2',3'-DIDEOXYNUCLEOSIDES OF 2-AMINOPURINE

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UNSPECIFIED (1992) THE ENZYMATIC-SYNTHESIS AND ANTI-HIV ACTIVITY OF 9-BETA-D-2'-DEOXY AND 9-BETA-D-2',3'-DIDEOXYNUCLEOSIDES OF 2-AMINOPURINE. ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 3 (3). pp. 153-156.

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Abstract

The 9-beta-D-2'-deoxy and 9-beta-D-2',3'-dideoxyribonucleosides of 2-aminopurine have been prepared using crude nucleoside N-deoxyribosyltransferases (E.C. 2.4.2.6) from Lactobacillus leichmannii in the presence of 10% ethylene glycol to inhibit degradation of the product nucleosides. The 2',3'-dideoxynucleoside of 2-aminopurine is an inhibitor of the replication of HIV-1, HIV-2, and SIV with EC50 values in the range 8-100-mu-M depending on the cell line used and has low in vitro toxicity at its effective concentrations.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title: ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
Publisher: BLACKWELL SCIENCE LTD
ISSN: 0956-3202
Official Date: 1992
Dates:
DateEvent
1992UNSPECIFIED
Volume: 3
Number: 3
Number of Pages: 4
Page Range: pp. 153-156
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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