UNSPECIFIED (1991) COMPUTER-SIMULATION OF TUMOR KILLING USING RADIOLABELED ANTIBODIES. In: 3RD CONF ON RADIOIMMUNODETECTION AND RADIOIMMUNOTHERAPY OF CANCER, NOV 14-17, 1990, PRINCETON, NJ.

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Abstract

We have developed a non-linear compartmental model incorporating saturable binding to calculate the antibody characteristics and optimal radiation for killing tumours with I-131 and Y-90 labelled antibodies. The model is represented by a series of stiff differential equations which have been solved using the FACSIMILE computer package combined with the SAS graphics package and MIRD radiation dosimetry tables. Results show that a 60 Gray killing dose to the tumour requires a much higher tumour uptake of antibody than presently achieved. Essential antibody characteristics are high affinity combined with the optimal dose for each patient.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine
Journal or Publication Title:	ANTIBODY IMMUNOCONJUGATES AND RADIOPHARMACEUTICALS
Publisher:	MARY ANN LIEBERT INC PUBL
ISSN:	0892-7049
Date:	1991
Volume:	4
Number:	4
Number of Pages:	7
Page Range:	pp. 745-751
Publication Status:	Published
Title of Event:	3RD CONF ON RADIOIMMUNODETECTION AND RADIOIMMUNOTHERAPY OF CANCER
Location of Event:	PRINCETON, NJ
Date(s) of Event:	NOV 14-17, 1990
URI:	http://wrap.warwick.ac.uk/id/eprint/22062

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