COMPUTER-SIMULATION OF TUMOR KILLING USING RADIOLABELED ANTIBODIES
UNSPECIFIED (1991) COMPUTER-SIMULATION OF TUMOR KILLING USING RADIOLABELED ANTIBODIES. In: 3RD CONF ON RADIOIMMUNODETECTION AND RADIOIMMUNOTHERAPY OF CANCER, PRINCETON, NJ, NOV 14-17, 1990. Published in: ANTIBODY IMMUNOCONJUGATES AND RADIOPHARMACEUTICALS, 4 (4). pp. 745-751.Full text not available from this repository.
We have developed a non-linear compartmental model incorporating saturable binding to calculate the antibody characteristics and optimal radiation for killing tumours with I-131 and Y-90 labelled antibodies. The model is represented by a series of stiff differential equations which have been solved using the FACSIMILE computer package combined with the SAS graphics package and MIRD radiation dosimetry tables. Results show that a 60 Gray killing dose to the tumour requires a much higher tumour uptake of antibody than presently achieved. Essential antibody characteristics are high affinity combined with the optimal dose for each patient.
|Item Type:||Conference Item (UNSPECIFIED)|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology
|Journal or Publication Title:||ANTIBODY IMMUNOCONJUGATES AND RADIOPHARMACEUTICALS|
|Publisher:||MARY ANN LIEBERT INC PUBL|
|Number of Pages:||7|
|Page Range:||pp. 745-751|
|Title of Event:||3RD CONF ON RADIOIMMUNODETECTION AND RADIOIMMUNOTHERAPY OF CANCER|
|Location of Event:||PRINCETON, NJ|
|Date(s) of Event:||NOV 14-17, 1990|
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