PROTECTION OF MICE FROM LETHAL INFLUENZA BY DEFECTIVE INTERFERING VIRUS - T-CELL RESPONSES
UNSPECIFIED. (1992) PROTECTION OF MICE FROM LETHAL INFLUENZA BY DEFECTIVE INTERFERING VIRUS - T-CELL RESPONSES. JOURNAL OF GENERAL VIROLOGY, 73 (Part 2). pp. 375-381. ISSN 0022-1317Full text not available from this repository.
The immune-mediated lethal influenza in C3H/He-mg (H-2k) mice infected with A/WSN influenza virus (H1N1) was investigated. A primary class I major histocompatibility complex-restricted, CD8+ cytotoxic T lymphocyte (CTL) response was found in the lungs with a peak activity at 5 days post-infection. Monoclonal antibody depletion in vivo showed that a lethal CD8+ cell response as well as a lethal CD4+ response was generated during infection. Mice survived infection only if both CD8+ and CD4+ cells were depleted. Mice infected with the same dose of virus, but treated with defective interfering (DI) A/WSN virus develop only a transient sub-lethal respiratory disease even though multiplication of virus in the lungs is undiminished, and we have shown here that this correlates with a reduction in the local CTL response. The mechanism by which DI virus beneficially modulates the immune response is discussed; it is proposed that there is classical, but cell type-specific DI virus interference in lymphocytes but not in the cells of the lung in which virus multiplies productively.
|Item Type:||Journal Article|
|Subjects:||T Technology > TP Chemical technology
Q Science > QR Microbiology > QR355 Virology
|Journal or Publication Title:||JOURNAL OF GENERAL VIROLOGY|
|Publisher:||SOC GENERAL MICROBIOLOGY|
|Number of Pages:||7|
|Page Range:||pp. 375-381|
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