The Library
PROTECTION OF MICE FROM LETHAL INFLUENZA BY DEFECTIVE INTERFERING VIRUS - T-CELL RESPONSES
Tools
UNSPECIFIED (1992) PROTECTION OF MICE FROM LETHAL INFLUENZA BY DEFECTIVE INTERFERING VIRUS - T-CELL RESPONSES. JOURNAL OF GENERAL VIROLOGY, 73 (Part 2). pp. 375-381. ISSN 0022-1317.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Abstract
The immune-mediated lethal influenza in C3H/He-mg (H-2k) mice infected with A/WSN influenza virus (H1N1) was investigated. A primary class I major histocompatibility complex-restricted, CD8+ cytotoxic T lymphocyte (CTL) response was found in the lungs with a peak activity at 5 days post-infection. Monoclonal antibody depletion in vivo showed that a lethal CD8+ cell response as well as a lethal CD4+ response was generated during infection. Mice survived infection only if both CD8+ and CD4+ cells were depleted. Mice infected with the same dose of virus, but treated with defective interfering (DI) A/WSN virus develop only a transient sub-lethal respiratory disease even though multiplication of virus in the lungs is undiminished, and we have shown here that this correlates with a reduction in the local CTL response. The mechanism by which DI virus beneficially modulates the immune response is discussed; it is proposed that there is classical, but cell type-specific DI virus interference in lymphocytes but not in the cells of the lung in which virus multiplies productively.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | T Technology > TP Chemical technology Q Science > QR Microbiology > QR355 Virology |
||||
Journal or Publication Title: | JOURNAL OF GENERAL VIROLOGY | ||||
Publisher: | SOC GENERAL MICROBIOLOGY | ||||
ISSN: | 0022-1317 | ||||
Official Date: | February 1992 | ||||
Dates: |
|
||||
Volume: | 73 | ||||
Number: | Part 2 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 375-381 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |