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EFFECT OF CHANGES IN THE NUCLEOTIDE-SEQUENCE OF THE P-GENE OF RESPIRATORY SYNCYTIAL VIRUS ON THE ELECTROPHORETIC MOBILITY OF THE P-PROTEIN
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UNSPECIFIED (1992) EFFECT OF CHANGES IN THE NUCLEOTIDE-SEQUENCE OF THE P-GENE OF RESPIRATORY SYNCYTIAL VIRUS ON THE ELECTROPHORETIC MOBILITY OF THE P-PROTEIN. VIRUS GENES, 6 (1). pp. 53-62. ISSN 0920-8569
Full text not available from this repository.Abstract
A consensus sequence for the P protein gene of the RSN-2 strain of respiratory syncytial (RS) virus was obtained by PCR amplification of cDNA obtained by reverse transcription. This established that the extent of sequence variation between two P genes of strains of antigenic subtype B is similar to that among A strains, confirming the conservation of P genes within subtypes and the divergence of the two antigenic subtypes of RS virus. The P protein of RS virus exhibits anomalous electrophoretic mobility with respect to its molecular weight. In vitro transcription and translation of RSN-2 strain cDNA possessing single point mutations revealed that substitutions involving charged amino acids in the carboxy-terminal region had a marked effect on the electrophoretic mobility of the P protein.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology > QR355 Virology |
| Journal or Publication Title: | VIRUS GENES |
| Publisher: | KLUWER ACADEMIC PUBL |
| ISSN: | 0920-8569 |
| Date: | January 1992 |
| Volume: | 6 |
| Number: | 1 |
| Number of Pages: | 10 |
| Page Range: | pp. 53-62 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/22261 |
Data sourced from Thomson Reuters' Web of Knowledge
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