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EFFECT OF CHANGES IN THE NUCLEOTIDE-SEQUENCE OF THE P-GENE OF RESPIRATORY SYNCYTIAL VIRUS ON THE ELECTROPHORETIC MOBILITY OF THE P-PROTEIN
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UNSPECIFIED (1992) EFFECT OF CHANGES IN THE NUCLEOTIDE-SEQUENCE OF THE P-GENE OF RESPIRATORY SYNCYTIAL VIRUS ON THE ELECTROPHORETIC MOBILITY OF THE P-PROTEIN. VIRUS GENES, 6 (1). pp. 53-62. ISSN 0920-8569.
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Abstract
A consensus sequence for the P protein gene of the RSN-2 strain of respiratory syncytial (RS) virus was obtained by PCR amplification of cDNA obtained by reverse transcription. This established that the extent of sequence variation between two P genes of strains of antigenic subtype B is similar to that among A strains, confirming the conservation of P genes within subtypes and the divergence of the two antigenic subtypes of RS virus.
The P protein of RS virus exhibits anomalous electrophoretic mobility with respect to its molecular weight. In vitro transcription and translation of RSN-2 strain cDNA possessing single point mutations revealed that substitutions involving charged amino acids in the carboxy-terminal region had a marked effect on the electrophoretic mobility of the P protein.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology > QR355 Virology |
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| Journal or Publication Title: | VIRUS GENES | ||||
| Publisher: | KLUWER ACADEMIC PUBL | ||||
| ISSN: | 0920-8569 | ||||
| Official Date: | January 1992 | ||||
| Dates: |
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| Volume: | 6 | ||||
| Number: | 1 | ||||
| Number of Pages: | 10 | ||||
| Page Range: | pp. 53-62 | ||||
| Publication Status: | Published |
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