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EFFECT OF CHANGES IN THE NUCLEOTIDE-SEQUENCE OF THE P-GENE OF RESPIRATORY SYNCYTIAL VIRUS ON THE ELECTROPHORETIC MOBILITY OF THE P-PROTEIN

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UNSPECIFIED (1992) EFFECT OF CHANGES IN THE NUCLEOTIDE-SEQUENCE OF THE P-GENE OF RESPIRATORY SYNCYTIAL VIRUS ON THE ELECTROPHORETIC MOBILITY OF THE P-PROTEIN. VIRUS GENES, 6 (1). pp. 53-62. ISSN 0920-8569.

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Abstract

A consensus sequence for the P protein gene of the RSN-2 strain of respiratory syncytial (RS) virus was obtained by PCR amplification of cDNA obtained by reverse transcription. This established that the extent of sequence variation between two P genes of strains of antigenic subtype B is similar to that among A strains, confirming the conservation of P genes within subtypes and the divergence of the two antigenic subtypes of RS virus.

The P protein of RS virus exhibits anomalous electrophoretic mobility with respect to its molecular weight. In vitro transcription and translation of RSN-2 strain cDNA possessing single point mutations revealed that substitutions involving charged amino acids in the carboxy-terminal region had a marked effect on the electrophoretic mobility of the P protein.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title: VIRUS GENES
Publisher: KLUWER ACADEMIC PUBL
ISSN: 0920-8569
Official Date: January 1992
Dates:
DateEvent
January 1992UNSPECIFIED
Volume: 6
Number: 1
Number of Pages: 10
Page Range: pp. 53-62
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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