UNSPECIFIED (1992) DEFECTIVE INTERFERING INFLUENZA-VIRUS INHIBITS IMMUNOPATHOLOGICAL EFFECTS OF INFECTIOUS VIRUS IN THE MOUSE. JOURNAL OF VIROLOGY, 66 (2). pp. 1188-1192. ISSN 0022-538X

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Abstract

Mice inoculated intranasally with a lethal dose of standard influenza virus die with an immune-mediated pneumonia but are protected by coinculation with defective interfering (DI) virus. Here we show that recruitment of immune cells into the infected lung is halved by treatment with DI virus although the CD4+/CD8+ cell ratio is not affected. Responsiveness of lung T and B cells to lectins is inhibited by standard virus, but coinoculation of mice with DI virus causes a 13-fold increase in T-cell proliferation and up to a 100-fold increase in immunoglobulin production. This effect appears to be due to lymphocyte-specific DI virus-mediated interference, since there is no inhibition of virus multiplication in the lungs. The net result is a shift from a lethal to a beneficial immune response.

Item Type:	Journal Item
Subjects:	Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF VIROLOGY
Publisher:	AMER SOC MICROBIOLOGY
ISSN:	0022-538X
Date:	February 1992
Volume:	66
Number:	2
Number of Pages:	5
Page Range:	pp. 1188-1192
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/22281

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