UNSPECIFIED (1991) IDENTIFICATION OF A SPLEEN CELL-DERIVED FACTOR THAT INHIBITS SENSITIZATION OF MURINE PERITONEAL MAST-CELLS AS INTERFERON-GAMMA. In: 18TH SYMP OF THE COLLEQIUM-INTERNATIONALE-ALLERGOLOGICUM ON CELLULAR AND MOLECULAR NETWORKS IN CLINICAL IMMUNOLOGY AND ALLERGY, FUNCHAL, PORTUGAL, SEP 22-26, 1990. Published in: INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 94 (1-4). pp. 179-180. ISSN 0020-5915.

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Abstract

We present evidence that a spleen cell-derived factor that inhibits the sensitization of mouse peritoneal mast cells is IFN-gamma. Conditioned medium (CM) from Con A-activated mouse spleen cells and recombinant MuIFN-gamma both inhibited antigen-induced 5-HT release from peritoneal mast cells when added at the sensitization stage, but were without effect on presensitized cells. Both preparations were active at dilutions corresponding to similar levels of IFN activity (1-10 units/ml). The inhibitory activity of CM was blocked by a rat monoclonal MuIFN-gamma-neutralizing antibody, thus confirming that IFN-gamma was the active molecule.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	R Medicine > RA Public aspects of medicine Q Science > QR Microbiology > QR180 Immunology
Journal or Publication Title:	INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY
Publisher:	KARGER
ISSN:	0020-5915
Official Date:	1991
Dates:	Date Event 1991 UNSPECIFIED
Volume:	94
Number:	1-4
Number of Pages:	2
Page Range:	pp. 179-180
Publication Status:	Published
Title of Event:	18TH SYMP OF THE COLLEQIUM-INTERNATIONALE-ALLERGOLOGICUM ON CELLULAR AND MOLECULAR NETWORKS IN CLINICAL IMMUNOLOGY AND ALLERGY
Location of Event:	FUNCHAL, PORTUGAL
Date(s) of Event:	SEP 22-26, 1990

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