IDENTIFICATION OF A SPLEEN CELL-DERIVED FACTOR THAT INHIBITS SENSITIZATION OF MURINE PERITONEAL MAST-CELLS AS INTERFERON-GAMMA
UNSPECIFIED (1991) IDENTIFICATION OF A SPLEEN CELL-DERIVED FACTOR THAT INHIBITS SENSITIZATION OF MURINE PERITONEAL MAST-CELLS AS INTERFERON-GAMMA. In: 18TH SYMP OF THE COLLEQIUM-INTERNATIONALE-ALLERGOLOGICUM ON CELLULAR AND MOLECULAR NETWORKS IN CLINICAL IMMUNOLOGY AND ALLERGY, SEP 22-26, 1990, FUNCHAL, PORTUGAL.Full text not available from this repository.
We present evidence that a spleen cell-derived factor that inhibits the sensitization of mouse peritoneal mast cells is IFN-gamma. Conditioned medium (CM) from Con A-activated mouse spleen cells and recombinant MuIFN-gamma both inhibited antigen-induced 5-HT release from peritoneal mast cells when added at the sensitization stage, but were without effect on presensitized cells. Both preparations were active at dilutions corresponding to similar levels of IFN activity (1-10 units/ml). The inhibitory activity of CM was blocked by a rat monoclonal MuIFN-gamma-neutralizing antibody, thus confirming that IFN-gamma was the active molecule.
|Item Type:||Conference Item (UNSPECIFIED)|
|Subjects:||R Medicine > RA Public aspects of medicine
Q Science > QR Microbiology > QR180 Immunology
|Journal or Publication Title:||INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY|
|Number of Pages:||2|
|Page Range:||pp. 179-180|
|Title of Event:||18TH SYMP OF THE COLLEQIUM-INTERNATIONALE-ALLERGOLOGICUM ON CELLULAR AND MOLECULAR NETWORKS IN CLINICAL IMMUNOLOGY AND ALLERGY|
|Location of Event:||FUNCHAL, PORTUGAL|
|Date(s) of Event:||SEP 22-26, 1990|
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