UNSPECIFIED. (1991) PROMOTER-SPECIFIC TRANSACTIVATION OF HEPATITIS-B VIRUS TRANSCRIPTION BY A GLUTAMINE-RICH AND PROLINE-RICH DOMAIN OF HEPATOCYTE NUCLEAR FACTOR-I. JOURNAL OF VIROLOGY, 65 (11). pp. 5774-5781. ISSN 0022-538X

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Abstract

The cloned transcription factor hepatocyte nuclear factor 1 (HNF1) transactivates transcription from the hepatitis B virus (HBV) large surface antigen promoter but does not influence the transcriptional activities of the other three HBV promoters. This indicates that this transcription factor can differentially influence the activities of the HBV promoters. By using a transient-transfection system, the major domain of the HNF1 polypeptide involved in transcriptional activation of the large surface antigen promoter in the human hepatoma cell line HepG2.1 has been mapped to a region that is rich in glutamine and proline residues (9 of 18) and is different from the previously identified regions of this factor responsible for in vitro transcriptional activation of a promoter containing human albumin promoter HNF1 binding sites. The human albumin promoter HNF1 binding site mediates transcriptional activation through the same HNF1 polypeptide domain as the HBV large surface antigen promoter HNF1 binding site in transient-transfection assays with HepG2.1 cells, suggesting that HNF1 may possess multiple transcriptional activation domains.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF VIROLOGY
Publisher:	AMER SOC MICROBIOLOGY
ISSN:	0022-538X
Date:	November 1991
Volume:	65
Number:	11
Number of Pages:	8
Page Range:	pp. 5774-5781
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/22413

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