UNSPECIFIED. (1991) GENE-1 AND GENE-2 OF PNEUMONIA VIRUS OF MICE ENCODE PROTEINS WHICH HAVE LITTLE HOMOLOGY WITH THE 1C AND 1B PROTEINS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS. JOURNAL OF GENERAL VIROLOGY, 72 (Part 10). pp. 2545-2549. ISSN 0022-1317

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Abstract

Genes 1 and 2 of pneumonia virus of mice (PVM) consist of 410 and 571 nucleotides and encode proteins of 113 and 156 amino acids respectively. The proteins show no extensive (gene 1 analogous to 1C) or low (gene 2 analogous to 1B) homology to their presumed counterparts in human respiratory syncytial virus (HRSV). The strongest homology is between regions of approximately 35 amino acids located near the carboxy termini of the gene 2 product and the 1B protein with 29% identity, although a lower level of homology can be detected throughout much of these proteins (18% identity overall). These observations contrast with the conservation of 1C and 1B proteins between subgroups of HRSV and with the conservation of nucleocapsid proteins between HRSV and PVM.

Item Type:	Journal Article
Subjects:	T Technology > TP Chemical technology Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF GENERAL VIROLOGY
Publisher:	SOC GENERAL MICROBIOLOGY
ISSN:	0022-1317
Official Date:	October 1991
Dates:	Date Event October 1991 UNSPECIFIED
Volume:	72
Number:	Part 10
Number of Pages:	5
Page Range:	pp. 2545-2549
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/22426

Data sourced from Thomson Reuters' Web of Knowledge

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