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COXSACKIE-VIRUS B4 INFECTION OF THE MOUSE PANCREAS .1. DETECTION OF VIRUS-SPECIFIC RNA IN THE PANCREAS BY INSITU HYBRIDIZATION

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UNSPECIFIED (1991) COXSACKIE-VIRUS B4 INFECTION OF THE MOUSE PANCREAS .1. DETECTION OF VIRUS-SPECIFIC RNA IN THE PANCREAS BY INSITU HYBRIDIZATION. JOURNAL OF MEDICAL VIROLOGY, 35 (1). pp. 46-49.

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Abstract

The pathology of Coxsackie virus B4 (CVB4) infection in a murine model was investigated by in situ hybridisation using a biotinylated cDNA probe derived from CVB4. During the acute phase of infection virus RNA sequences were detected in the exocrine pancreas of 60% of mice infected with a pancreotropic variant of CVB4. A positive hybridisation signal was observed in other organs in some animals including the heart and liver of 1 mouse 28 days after infection. The cellular distribution of virus RNA sequences corresponded well with the histological findings in most tissues. Possible causes for failure of hybridisation in some infected pancreases are discussed in conjunction with potential application of the technique in human pancreas biopsy samples.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title: JOURNAL OF MEDICAL VIROLOGY
Publisher: WILEY-LISS
ISSN: 0146-6615
Official Date: September 1991
Dates:
DateEvent
September 1991UNSPECIFIED
Volume: 35
Number: 1
Number of Pages: 4
Page Range: pp. 46-49
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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