UNSPECIFIED (1991) NMR-STUDIES OF THE FLEXIBILITY OF THE GLYCOSYL RING IN THYMIDINE AND URIDINE NUCLEOSIDES. CARBOHYDRATE RESEARCH, 216 . pp. 1-9. ISSN 0008-6215

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Abstract

H-1-N.m.r. spectroscopy at various temperatures has been used to investigate the flexibility of the glycosyl ring and to calculate the percentage of N- and S-character in the most favoured conformations in solution adopted by various pyrimidine deoxyribonucleosides. The position and orientation of substituents have a definite and predictable influence on the conformation of the deoxyribose ring in these nucleosides. The deoxyribose rings in the nucleosides studied were, in general, flexible except for those of 3'-deoxy-3'-fluoro- and 3'-azido-3'-deoxy-thymidine and 2'-deoxy-2'-fluoro-5-methyl-arabinosyluracil.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	CARBOHYDRATE RESEARCH
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0008-6215
Date:	2 September 1991
Volume:	216
Number of Pages:	9
Page Range:	pp. 1-9
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/22458

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