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CHEMICAL SYNTHESIS OF 10-KDA CHAPERONIN - BIOLOGICAL-ACTIVITY SUGGESTS CHAPERONINS DO NOT REQUIRE OTHER MOLECULAR CHAPERONES

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UNSPECIFIED (1991) CHEMICAL SYNTHESIS OF 10-KDA CHAPERONIN - BIOLOGICAL-ACTIVITY SUGGESTS CHAPERONINS DO NOT REQUIRE OTHER MOLECULAR CHAPERONES. FEBS LETTERS, 286 (1-2). pp. 201-203. ISSN 0014-5793.

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Abstract

Molecular chaperones are required for the correct folding and assembly of certain other polypeptides. It is not known whether molecular chaperones themselves require other chaperones to become functional. A 97-amino acid chaperone, the chaperonin 10 protein was chemically synthesised so that during synthesis and purification there was no contact of the chaperone with any other protein. The purified, synthetic chaperonin 10 protein formed oligomeric structures spontaneously and was biologically active as a chaperonin. This is the first description of a chemically synthesised chaperonin, and suggests that no other chaperones are required for correct folding, polymerisation and biological activity of this chaperone.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Journal or Publication Title: FEBS LETTERS
Publisher: ELSEVIER SCIENCE BV
ISSN: 0014-5793
Official Date: 29 July 1991
Dates:
DateEvent
29 July 1991UNSPECIFIED
Volume: 286
Number: 1-2
Number of Pages: 3
Page Range: pp. 201-203
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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