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Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster

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Barrett, Perry, van den Top, Marco, Wilson, D., Mercer, Julian G., Song, C. K., Bartness, Timothy J., Morgan, Peter J. and Spanswick, David C.. (2009) Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster. Endocrinology, Vol.150 (No.8). pp. 3655-3663. ISSN 0013-7227

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Official URL: http://dx.doi.org/10.1210/en.2008-1620

Abstract

Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage. Little is known, however, of the hypothalamic neuronal events that lead to a change in behavior or physiology. Here we show for the first time that a shift from long summer-like to short inter-like photoperiod, which induces physiological adaptation to winter in the Siberian hamster, including a body weight decrease of up to 30%, increases neuronal activity in the dorsomedial region of the arcuate nucleus (dmpARC) assessed by electro physiological patch-clamping recording. Increased neuronal activity in short days is dependent on a photoperiod-driven down-regulation of H3 receptor expression and can be mimicked in long-day dmpARC neurons by the application of the H3 receptor antagonist, clobenproprit. Short-day activation of dmpARC neurons results in increased c-Fos expression. Tract tracing with the trans-synaptic retrograde tracer, pseudorabies virus, delivered into adipose tissue reveals a multisynaptic neuronal sympathetic outflow from dmpARC to white adipose tissue. These data strongly suggest that increased activity of dmpARC neurons, as a consequence of down-regulation of the histamine H3 receptor, contributes to the physiological adaptation of body weight regulation in seasonal photoperiod.

Item Type:

Journal Article

Subjects:

Q Science > QL Zoology
Q Science > QP Physiology

Divisions:

Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School

Library of Congress Subject Headings (LCSH):

Photoperiodism -- Research, Histamine -- Receptors, Hypothalamus, Body weight -- Regulation, Biological control systems, Hamsters -- Anatomy

Journal or Publication Title:

Endocrinology

Publisher:

The Endocrine Society

ISSN:

0013-7227

Official Date:

August 2009

Dates:

Date	Event
August 2009	Published

Volume:

Vol.150

Number:

No.8

Page Range:

pp. 3655-3663

Identification Number:

10.1210/en.2008-1620

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Seventh Framework Programme (European Commission) (FP7), Scotland. Rural and Environment Research and Analysis Directorate (RERAD), Great Britain. National Health Service (NHS)

Grant number:

LSHM-CT-2003-503041 (FP7)

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