ROLE OF ONCOGENES IN THE REGULATION OF MHC ANTIGEN EXPRESSION
UNSPECIFIED (1991) ROLE OF ONCOGENES IN THE REGULATION OF MHC ANTIGEN EXPRESSION. In: 637TH MEETING OF THE BIOCHEMICAL SOC, UNIV BIRMINGHAM, BIRMINGHAM, ENGLAND, DEC 18-20, 1990. Published in: BIOCHEMICAL SOCIETY TRANSACTIONS, 19 (2). pp. 291-296.Full text not available from this repository.
Class I and class II major histocompatibility complex (MHC) antigens are required for CD8+ cytotoxic T cells and CD4+ helper T-cells, respectively, to recognize foreign antigen. Regulating the levels of expression of these MHC antigens regulates the T-cell responses . This regulation is mainly carried out by the interferons (IFN), which are produced in the disease state. Type I IFN (IFN alpha or IFN-beta; collectively 'IFN-alpha-beta') up-regulates class I MHC and IFN-gamma up-regulates class I and class II MHC. We and others [1-3] have shown that transfection of cells with a variety of oncogenes including ras and myc affects the level of MHC antigen expression. This and other data provide evidence for a scheme in which the signal transduction mechanisms whereby IFN up-regulates MHC antigens involve several (proto)oncogenes.
|Item Type:||Conference Item (UNSPECIFIED)|
|Subjects:||Q Science > QD Chemistry|
|Journal or Publication Title:||BIOCHEMICAL SOCIETY TRANSACTIONS|
|Number of Pages:||6|
|Page Range:||pp. 291-296|
|Title of Event:||637TH MEETING OF THE BIOCHEMICAL SOC|
|Location of Event:||UNIV BIRMINGHAM, BIRMINGHAM, ENGLAND|
|Date(s) of Event:||DEC 18-20, 1990|
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