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ROLE OF ONCOGENES IN THE REGULATION OF MHC ANTIGEN EXPRESSION
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UNSPECIFIED (1991) ROLE OF ONCOGENES IN THE REGULATION OF MHC ANTIGEN EXPRESSION. In: 637TH MEETING OF THE BIOCHEMICAL SOC, UNIV BIRMINGHAM, BIRMINGHAM, ENGLAND, DEC 18-20, 1990. Published in: BIOCHEMICAL SOCIETY TRANSACTIONS, 19 (2). pp. 291-296. ISSN 0300-5127.
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Abstract
Class I and class II major histocompatibility complex (MHC) antigens are required for CD8+ cytotoxic T cells and CD4+ helper T-cells, respectively, to recognize foreign antigen. Regulating the levels of expression of these MHC antigens regulates the T-cell responses [1]. This regulation is mainly carried out by the interferons (IFN), which are produced in the disease state. Type I IFN (IFN alpha or IFN-beta; collectively 'IFN-alpha-beta') up-regulates class I MHC and IFN-gamma up-regulates class I and class II MHC. We and others [1-3] have shown that transfection of cells with a variety of oncogenes including ras and myc affects the level of MHC antigen expression. This and other data provide evidence for a scheme in which the signal transduction mechanisms whereby IFN up-regulates MHC antigens involve several (proto)oncogenes.
Item Type: | Conference Item (UNSPECIFIED) | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | BIOCHEMICAL SOCIETY TRANSACTIONS | ||||
Publisher: | PORTLAND PRESS | ||||
ISSN: | 0300-5127 | ||||
Official Date: | April 1991 | ||||
Dates: |
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Volume: | 19 | ||||
Number: | 2 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 291-296 | ||||
Publication Status: | Published | ||||
Title of Event: | 637TH MEETING OF THE BIOCHEMICAL SOC | ||||
Location of Event: | UNIV BIRMINGHAM, BIRMINGHAM, ENGLAND | ||||
Date(s) of Event: | DEC 18-20, 1990 |
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