Dunbar, Mark Robert, 1974- (2008) Patient factors associated with outcome after total knee replacement: research towards the design of a multicenter prospective cohort study. PhD thesis, University of Warwick.

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Abstract

This thesis set out to explore the influence of patient factors that may be associated with outcome after total knee replacement for osteoarthritis. It starts with an introduction to the general subject, looking in detail at the methods for measuring the outcome of total knee replacement and also methods of measuring the status of various possible patient factors. This is followed by a systematic review of the evidence currently available on the influence of patient factors on the outcome of total knee replacement. This systematic review highlights a number of deficiencies in the available evidence. The next logical step was to perform an appropriate study to provide better quality evidence. However, there were six areas of uncertainty that presented significant difficulty when designing such a study. These areas of uncertainty became the focus of this thesis and were explored in detail. Through a process of experimentation and careful evaluation of the results these uncertainties were resolved. This thesis has provided the critical information required to design and conduct a multicentre study that would define which patient factors are important in determining outcome for total knee replacement for osteoarthritis.

Item Type:	Thesis or Dissertation (PhD)
Subjects:	R Medicine > RD Surgery
Library of Congress Subject Headings (LCSH):	Total knee replacement, Knee -- Surgery, Surgery -- Risk factors -- Research, Medical history taking -- Research
Date:	December 2008
Institution:	University of Warwick
Theses Department:	Warwick Medical School
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Griffin, Damian R. ; Thorogood, Margaret
Extent:	329 leaves : ill., charts
Language:	eng
URI:	http://wrap.warwick.ac.uk/id/eprint/2269

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