OPTIMAL TUMOR TARGETING BY ANTIBODIES - DEVELOPMENT OF A MATHEMATICAL-MODEL
UNSPECIFIED. (1991) OPTIMAL TUMOR TARGETING BY ANTIBODIES - DEVELOPMENT OF A MATHEMATICAL-MODEL. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 19 (2). pp. 227-260. ISSN 0090-466XFull text not available from this repository.
A mathematical model has been developed to optimize tumor targeting with labeled antibodies. The model is compartmental and nonlinear, incorporating saturable binding. Published parameter values have been used in the model, and the resulting stiff differential equations have been solved using FACSIMILE, a computer package that can simulate very stiff differential systems. Results show that successful tumor targeting depends on an optimal combination of antibody dose, affinity, and molecular size. The model has allowed an assessment to be made of the complicated and interrelated dynamic relationships that these factors have on tumor targeting. It has also offered an explanation for previously unsatisfactory results from tumor targeting with labeled antibodies. The structural identifiability of the model parameters is also analyzed and it is shown that, with the prior knowledge of some parameters which is likely in practice, the remaining model parameters are uniquely identifiable.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Journal or Publication Title:||JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS|
|Publisher:||PLENUM PUBL CORP|
|Number of Pages:||34|
|Page Range:||pp. 227-260|
Actions (login required)