UNSPECIFIED (1991) OPTIMAL TUMOR TARGETING BY ANTIBODIES - DEVELOPMENT OF A MATHEMATICAL-MODEL. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 19 (2). pp. 227-260. ISSN 0090-466X.

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Abstract

A mathematical model has been developed to optimize tumor targeting with labeled antibodies. The model is compartmental and nonlinear, incorporating saturable binding. Published parameter values have been used in the model, and the resulting stiff differential equations have been solved using FACSIMILE, a computer package that can simulate very stiff differential systems. Results show that successful tumor targeting depends on an optimal combination of antibody dose, affinity, and molecular size. The model has allowed an assessment to be made of the complicated and interrelated dynamic relationships that these factors have on tumor targeting. It has also offered an explanation for previously unsatisfactory results from tumor targeting with labeled antibodies. The structural identifiability of the model parameters is also analyzed and it is shown that, with the prior knowledge of some parameters which is likely in practice, the remaining model parameters are uniquely identifiable.

Item Type:	Journal Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Journal or Publication Title:	JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS
Publisher:	PLENUM PUBL CORP
ISSN:	0090-466X
Official Date:	April 1991
Dates:	Date Event April 1991 UNSPECIFIED
Volume:	19
Number:	2
Number of Pages:	34
Page Range:	pp. 227-260
Publication Status:	Published

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