REDUCED STIMULATION OF HELPER T-CELLS BY KI-RAS TRANSFORMED-CELLS
UNSPECIFIED. (1991) REDUCED STIMULATION OF HELPER T-CELLS BY KI-RAS TRANSFORMED-CELLS. IMMUNOLOGY, 72 (2). pp. 277-281. ISSN 0019-2805Full text not available from this repository.
A number of viral genes and cellular oncogenes inhibit major histocompatibility complex (MHC) antigen expression at the cell surface. In the case of the inhibition of class I MHC antigens by viral genes this results in a reduced recognition by antigen-specific cytotoxic T cells. The activated Ki-ras cellular oncogene carried by the Ki-murine sarcoma virus (Ki-MuSV) in contrast inhibits class II MHC (or Ia) antigen expression on transformed cells. We have studied how transformation with Ki-ras affects recognition by alloreactive helper T cells. We found that the Ki-ras inhibition of class II MHC antigen expression led to greatly reduced stimulation of alloreactive T cells to proliferate and to secrete interferon-gamma (IFN-gamma). These findings support our hypothesis that the ability of an oncogene to reduce class II MHC antigen expression is crucial to its ability to produce tumour cells.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology|
|Journal or Publication Title:||IMMUNOLOGY|
|Publisher:||BLACKWELL SCIENCE LTD|
|Official Date:||February 1991|
|Number of Pages:||5|
|Page Range:||pp. 277-281|
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