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REDUCED STIMULATION OF HELPER T-CELLS BY KI-RAS TRANSFORMED-CELLS
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UNSPECIFIED (1991) REDUCED STIMULATION OF HELPER T-CELLS BY KI-RAS TRANSFORMED-CELLS. IMMUNOLOGY, 72 (2). pp. 277-281. ISSN 0019-2805
Full text not available from this repository.Abstract
A number of viral genes and cellular oncogenes inhibit major histocompatibility complex (MHC) antigen expression at the cell surface. In the case of the inhibition of class I MHC antigens by viral genes this results in a reduced recognition by antigen-specific cytotoxic T cells. The activated Ki-ras cellular oncogene carried by the Ki-murine sarcoma virus (Ki-MuSV) in contrast inhibits class II MHC (or Ia) antigen expression on transformed cells. We have studied how transformation with Ki-ras affects recognition by alloreactive helper T cells. We found that the Ki-ras inhibition of class II MHC antigen expression led to greatly reduced stimulation of alloreactive T cells to proliferate and to secrete interferon-gamma (IFN-gamma). These findings support our hypothesis that the ability of an oncogene to reduce class II MHC antigen expression is crucial to its ability to produce tumour cells.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Journal or Publication Title: | IMMUNOLOGY |
| Publisher: | BLACKWELL SCIENCE LTD |
| ISSN: | 0019-2805 |
| Date: | February 1991 |
| Volume: | 72 |
| Number: | 2 |
| Number of Pages: | 5 |
| Page Range: | pp. 277-281 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/22839 |
Data sourced from Thomson Reuters' Web of Knowledge
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