The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya
Ochola, Rachel, Sande, Charles, Fegan, Greg, Scott, P. D. (Paul D.), Medley, Graham, Cane, Patricia and Nokes, D. James. (2009) The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya. PLoS One, Vol.4 (No.12). e8088. ISSN 1932-6203
WRAP_Medley_Kilifi_Kenya.pdf - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Official URL: http://dx.doi.org/10.1371/journal.pone.0008088
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in infants. The rate of decay of RSV-specific maternal antibodies (RSV-matAb), the factors affecting cord blood levels, and the relationship between these levels and protection from infection are poorly defined.
A birth cohort (n = 635) in rural Kenya, was studied intensively to monitor infections and describe age-related serological characteristics. RSV specific IgG antibody (Ab) in serum was measured by the enzyme linked immunosorbent assay (ELISA) in cord blood, consecutive samples taken 3 monthly, and in paired acute and convalescent samples. A linear regression model was used to calculate the rate of RSV-matAb decline. The effect of risk factors on cord blood titres was investigated.
The half-life of matAb in the Kenyan cohort was calculated to be 79 days (95% confidence limits (CL): 76–81 days). Ninety seven percent of infants were born with RSV-matAb. Infants who subsequently experienced an infection in early life had significantly lower cord titres of anti-RSV Ab in comparison to infants who did not have any incident infection in the first 6 months (P = 0.011). RSV infections were shown to have no effect on the rate of decay of RSV-matAb.
Maternal-specific RSV Ab decline rapidly following birth. However, we provide evidence of protection against severe disease by RSV-matAb during the first 6–7 months. This suggests that boosting maternal-specific Ab by RSV vaccination may be a useful strategy to consider.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RJ Pediatrics
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)|
|Library of Congress Subject Headings (LCSH):||Respiratory syncytial virus -- Kenya -- Kilifi District, Immunoglobulin G, Maternally acquired immunity -- Kenya -- Kilifi District, Communicable diseases -- Prevention, Enzyme-linked immunosorbent assay, Vaccination|
|Journal or Publication Title:||PLoS One|
|Publisher:||Public Library of Science|
|Official Date:||2 December 2009|
|Access rights to Published version:||Open Access|
|Funder:||Wellcome Trust (London, England)|
|Grant number:||061584 (WT), 076278 (WT)|
# Loscertales MP, Roca A, Ventura PJ, Abacassamo F, Dos Santos F, et al. (2002) Epidemiology and clinical presentation of respiratory syncytial virus infection in a rural area of southern Mozambique. Pediatr Infect Dis J 21: 148–55.
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