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The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya

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Ochola, Rachel, Sande, Charles, Fegan, Greg, Scott, P. D. (Paul D.), Medley, Graham, Cane, Patricia and Nokes, D. James. (2009) The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya. PLoS One, Vol.4 (No.12). e8088. ISSN 1932-6203

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Official URL: http://dx.doi.org/10.1371/journal.pone.0008088

Abstract

Background
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in infants. The rate of decay of RSV-specific maternal antibodies (RSV-matAb), the factors affecting cord blood levels, and the relationship between these levels and protection from infection are poorly defined.
Methods
A birth cohort (n = 635) in rural Kenya, was studied intensively to monitor infections and describe age-related serological characteristics. RSV specific IgG antibody (Ab) in serum was measured by the enzyme linked immunosorbent assay (ELISA) in cord blood, consecutive samples taken 3 monthly, and in paired acute and convalescent samples. A linear regression model was used to calculate the rate of RSV-matAb decline. The effect of risk factors on cord blood titres was investigated.
Results
The half-life of matAb in the Kenyan cohort was calculated to be 79 days (95% confidence limits (CL): 76–81 days). Ninety seven percent of infants were born with RSV-matAb. Infants who subsequently experienced an infection in early life had significantly lower cord titres of anti-RSV Ab in comparison to infants who did not have any incident infection in the first 6 months (P = 0.011). RSV infections were shown to have no effect on the rate of decay of RSV-matAb.
Conclusion
Maternal-specific RSV Ab decline rapidly following birth. However, we provide evidence of protection against severe disease by RSV-matAb during the first 6–7 months. This suggests that boosting maternal-specific Ab by RSV vaccination may be a useful strategy to consider.

Item Type:

Journal Article

Subjects:

R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RJ Pediatrics

Divisions:

Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)

Library of Congress Subject Headings (LCSH):

Respiratory syncytial virus -- Kenya -- Kilifi District, Immunoglobulin G, Maternally acquired immunity -- Kenya -- Kilifi District, Communicable diseases -- Prevention, Enzyme-linked immunosorbent assay, Vaccination

Journal or Publication Title:

PLoS One

Publisher:

Public Library of Science

ISSN:

1932-6203

Official Date:

2 December 2009

Dates:

Date	Event
2 December 2009	Published

Volume:

Vol.4

Number:

No.12

Page Range:

e8088

Identification Number:

10.1371/journal.pone.0008088

Status:

Peer Reviewed

Access rights to Published version:

Open Access

Funder:

Wellcome Trust (London, England)

Grant number:

061584 (WT), 076278 (WT)

References:

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