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Modelling the dynamics of intramammary E. coli infections in dairy cows: understanding mechanisms that distinguish transient from persistent infections
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White, L. J., Schukken, Y. H., Dogan, Belgin, Green, Laura E., Döpfer, Dörte, Chappell, M. J. (Michael J.) and Medley, Graham (2010) Modelling the dynamics of intramammary E. coli infections in dairy cows: understanding mechanisms that distinguish transient from persistent infections. Veterinary Research, Vol.41 (No.2). 15 pages. doi:10.1051/vetres/2009061
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Official URL: http://dx.doi.org/10.1051/vetres/2009061
Abstract
The majority of intramammary infections with Escherichia coli in dairy cows result in transient infections with duration of about 10 days or less, although more persistent infections (2 months or longer) have been identified. We apply a mathematical model to explore the role of an intracellular mammary epithelial cell reservoir in the dynamics of infection. We included biological knowledge of the bovine immune response and known characteristics of the bacterial population in both transient and persistent infections. The results indicate that varying the survival duration of the intracellular reservoir reproduces the data for both transient and persistent infections. Survival in an intracellular reservoir is the most likely mechanism that ensures persistence of E. coli infections in mammary glands. Knowledge of the pathogenesis of persistent infections is essential to develop preventive and treatment programmes for these important infections in dairy cows.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | S Agriculture > SF Animal culture | ||||
| Divisions: | Faculty of Science > Engineering Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) |
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| Library of Congress Subject Headings (LCSH): | Mastitis -- Research, Dairy cattle -- Infections -- Mathematical models, Communicable diseases in animals -- Mathematical models, Udder -- Microbiology -- Research, Escherichia coli infections in animals -- Mathematical models | ||||
| Journal or Publication Title: | Veterinary Research | ||||
| Publisher: | EDP Sciences | ||||
| ISSN: | 0928-4249 | ||||
| Official Date: | March 2010 | ||||
| Dates: |
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| Volume: | Vol.41 | ||||
| Number: | No.2 | ||||
| Page Range: | 15 pages | ||||
| DOI: | 10.1051/vetres/2009061 | ||||
| Status: | Peer Reviewed | ||||
| Access rights to Published version: | Open Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Wellcome Trust (London, England) | ||||
| Grant number: | BBS/S/04854 (BBSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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