Nicholas, R. (Richard), Chataway, Jeremy, Todd, S. C. (Susan C.), Stallard, Nigel, Valdés-Márquez, Elsa, Parsons, Nicholas R. and Friede, Tim (2009) Adaptive clinical trials incorporating treatment selection and evaluation: methodology and application in progressive multiple sclerosis. In: 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Düsseldorf, Germany, 9-12th September 2009

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Abstract

In progressive multiple sclerosis (MS) irreversible disability often takes many years to accumulate as a result prolonged trials are required to assess the benefits of therapies. There is a need to understand the relationship between short-term outcome measures such as MRI endpoints and long-term clinical outcomes in progression to determine the evolution of the disease early on. Thus, the common phase I-II-III paradigm for clinical trial design with separate trials for each phase may not be appropriate.

Item Type:	Conference Item (Poster)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Multiple sclerosis -- Research -- Congresses, Clinical trials -- Design, Clinical trials -- Methodology, Neurology -- Congresses
Official Date:	2009
Dates:	Date Event 2009 Published
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Adapted As:	Nicholas, R. et al. (2009). Adaptive clinical trials incorporating treatment selection and evaluation: methodology and application in progressive multiple sclerosis. Multiple Sclerosis, 15(9 Suppl.), pp. S142-S143.
Conference Paper Type:	Poster
Title of Event:	25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis
Type of Event:	Conference
Location of Event:	Düsseldorf, Germany
Date(s) of Event:	9-12th September 2009
URI:	http://wrap.warwick.ac.uk/id/eprint/2464

Data sourced from Thomson Reuters' Web of Knowledge

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