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Adaptive clinical trials incorporating treatment selection and evaluation: methodology and application in progressive multiple sclerosis
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Nicholas, R. (Richard), Chataway, Jeremy, Todd, S. C. (Susan C.), Stallard, Nigel, Valdés-Márquez, Elsa, Parsons, Nicholas R. and Friede, Tim (2009) Adaptive clinical trials incorporating treatment selection and evaluation: methodology and application in progressive multiple sclerosis. In: 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Düsseldorf, Germany, 9-12th September 2009
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PDF (Poster Summary)
WRAP_Stocks_ECTRIMS2009_abstract.pdf - Draft Version - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader Download (30Kb) |
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PDF (Poster)
WRAP_Stocks_ECTRIMS_2009_MS_AD.pdf - Draft Version - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader Download (67Kb) |
Abstract
In progressive multiple sclerosis (MS) irreversible disability often takes many years to accumulate as a result prolonged trials are required to assess the benefits of therapies. There is a need to understand the relationship between short-term outcome measures such as MRI endpoints and long-term clinical outcomes in progression to determine the evolution of the disease early on. Thus, the common phase I-II-III paradigm for clinical trial design with separate trials for each phase may not be appropriate.
| Item Type: | Conference Item (Poster) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Multiple sclerosis -- Research -- Congresses, Clinical trials -- Design, Clinical trials -- Methodology, Neurology -- Congresses |
| Official Date: | 2009 |
| Status: | Peer Reviewed |
| Access rights to Published version: | Open Access |
| Adapted As: | Nicholas, R. et al. (2009). Adaptive clinical trials incorporating treatment selection and evaluation: methodology and application in progressive multiple sclerosis. Multiple Sclerosis, 15(9 Suppl.), pp. S142-S143. |
| Conference Paper Type: | Poster |
| Title of Event: | 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis |
| Type of Event: | Conference |
| Location of Event: | Düsseldorf, Germany |
| Date(s) of Event: | 9-12th September 2009 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/2464 |
Data sourced from Thomson Reuters' Web of Knowledge
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