Schulz, David J., Baines, Richard A., Hempel, Chris M., Li, L. (Lingjun), Liss, Birgit and Misonou, Hiroaki. (2006) Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulation. Journal of Neuroscience, Vol.26 (No.41). pp. 10362-10367. ISSN 0270-6474

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Abstract

The intrinsic properties of a neuron determine the translation of synaptic input to axonal output. It is this input– output relationship that is the heart of all nervous system activity. As such, the overall regulation of the intrinsic excitability of a neuron directly determines the output of that neuron at a given point in time, giving the cell a unique “functional identity.” To maintain this distinct functional output, neurons must adapt to changing patterns of synaptic excitation. These adaptations are essential to prevent neurons from either falling silent as synaptic excitation falls or becoming saturated as excitation increases. In the absence of stabilizing mechanisms, activity-dependent plasticity could drive neural activity to saturation or quiescence. Furthermore, as cells adapt to changing patterns of synaptic input, presumably the overall balance of intrinsic conductances of the cell must be maintained so that reliable output is achieved (Daoudal and Debanne, 2003; Turrigiano and Nelson, 2004; Frick and Johnston, 2005). Although these regulatory phenomena have been well documented, the molecular and physiological mechanisms involved are poorly understood.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Excitation (Physiology) -- Research, Ion channels -- Research, Electrophysiology -- Research, Homeostasis, DNA microarrays
Journal or Publication Title:	Journal of Neuroscience
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Date:	11 October 2006
Volume:	Vol.26
Number:	No.41
Page Range:	pp. 10362-10367
Identification Number:	10.1523/JNEUROSCI.3194-06.2006
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Royal Society (Great Britain), Germany. Bundesministerium für Bildung und Forschung (BMBF), Hertie Foundation (HF), National Institutes of Health (U.S.) (NIH), University of Wisconsin--Madison, National Science Foundation (U.S.) (NSF), Alfred P. Sloan Foundation
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URI:	http://wrap.warwick.ac.uk/id/eprint/2556

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