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Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulation

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Schulz, David J., Baines, Richard A., Hempel, Chris M., Li, L. (Lingjun), Liss, Birgit and Misonou, Hiroaki. (2006) Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulation. Journal of Neuroscience, Vol.26 (No.41). pp. 10362-10367. ISSN 0270-6474

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Official URL: http://dx.doi.org/10.1523/JNEUROSCI.3194-06.2006

Abstract

The intrinsic properties of a neuron determine the translation of synaptic input to axonal output. It is this input– output relationship that is the heart of all nervous system activity. As such, the overall regulation of the intrinsic excitability of a neuron directly determines the output of that neuron at a given point in time, giving the cell a unique “functional identity.” To maintain this distinct functional output, neurons must adapt to changing patterns of synaptic excitation. These adaptations are essential to prevent neurons from either falling silent as synaptic excitation falls or becoming saturated as excitation increases. In the absence of stabilizing mechanisms, activity-dependent plasticity could drive neural activity to saturation or quiescence. Furthermore, as cells adapt to changing patterns of synaptic input, presumably the overall balance of intrinsic conductances of the cell must be maintained so that reliable output is achieved (Daoudal and Debanne, 2003; Turrigiano and Nelson, 2004; Frick and Johnston, 2005). Although these regulatory phenomena have been well documented, the molecular and physiological mechanisms involved are poorly understood.

Item Type:

Journal Article

Subjects:

R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

Divisions:

Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)

Library of Congress Subject Headings (LCSH):

Excitation (Physiology) -- Research, Ion channels -- Research, Electrophysiology -- Research, Homeostasis, DNA microarrays

Journal or Publication Title:

Journal of Neuroscience

Publisher:

Society for Neuroscience

ISSN:

0270-6474

Official Date:

11 October 2006

Dates:

Date	Event
11 October 2006	Published

Volume:

Vol.26

Number:

No.41

Page Range:

pp. 10362-10367

Identification Number:

10.1523/JNEUROSCI.3194-06.2006

Status:

Peer Reviewed

Access rights to Published version:

Open Access

Funder:

Royal Society (Great Britain), Germany. Bundesministerium für Bildung und Forschung (BMBF), Hertie Foundation (HF), National Institutes of Health (U.S.) (NIH), University of Wisconsin--Madison, National Science Foundation (U.S.) (NSF), Alfred P. Sloan Foundation

References:

Andrews ZB, Diano S, Horvath TL (2005) Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci 6:829–840.
Baines RA (2005) Neuronal homeostasis through translational control. Mol Neurobiol 32:113–121.
Baines RA, Pym EC (2006) Determinants of electrical properties in developing neurons. Semin Cell Dev Biol 17:12–19.
Brezina V, Weiss KR (1997) Functional consequences of divergence and convergence in physiological signalling pathways. Mol Psychiatry 2:9–11.
Chung CY, Seo H, Sonntag KC, Brooks A, Lin L, Isacson O (2005) Cell
type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. HumMol Genet 14:1709 –1725.
Cragg S, Rice ME, Greenfield SA (1997) Heterogeneity of electrically evoked dopamine release and reuptake in substantia nigra, ventral tegmental area, and striatum. J Neurophysiol 77:863– 873.
Cruz-Bermudez ND, Fu Q, Kutz-Naber KK, Christie AE, Li L, Marder E
(2006) Mass spectrometric characterization and physiological actions of GAHKNYLRFamide, a novel FMRFamide-like peptide from crabs of the genus Cancer. J Neurochem 97:784 –799.
Daoudal G, Debanne D (2003) Long-term plasticity of intrinsic excitability: learning rules and mechanisms. Learn Mem 10:456–465.
DeKeyser SS, Li L (2006) Mass spectrometric charting of neuropeptides in arthropod neurons. Anal Bioanal Chem, in press.
Du J, Haak LL, Phillips-Tansey E, Russell JT, McBain CJ (2000) Frequency dependent regulation of rat hippocampal somato-dendritic excitability by the K+ channel subunit Kv2.1. J Physiol (Lond) 522:19–31.
Frick A, Johnston D (2005) Plasticity of dendritic excitability. J Neurobiol 64:100 –115.
Fu Q, Li L (2005) De novo sequencing of neuropeptides using reductive isotopic methylation and investigation of ESI QTOF MS/MS fragmentation pattern of neuropeptides with N-terminal dimethylation. Anal Chem 77:7783–7795.
Fu Q, Goy MF, Li L (2005a) Identification of neuropeptides from the decapod crustacean sinus glands using nanoscale liquid chromatography tandem mass spectrometry. Biochem Biophys Res Commun 337:765–778.
Fu Q, Kutz KK, Schmidt JJ, Hsu YW, Messinger DI, Cain SD, de la Iglesia HO, Christie AE, Li L (2005b) Hormone complement of the Cancer productus sinus gland and pericardial organ: An anatomical and mass spectrometric investigation. J Comp Neurol 493:607– 626.
Greene JG, Dingledine R, Greenamyre JT (2005) Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism. Neurobiol Dis 18:19 –31.
Grimm J, Mueller A, Hefti F, Rosenthal A (2004) Molecular basis for catecholaminergic neuron diversity. Proc Natl Acad Sci USA
101:13891–13896.
Hyman SE, Malenka RC, Nestler EJ (2006) Neural mechanisms of addiction:the role of reward-related learning and memory. Annu Rev Neurosci 29:565–598.
Korotkova TM, Ponomarenko AA, Brown RE, Haas HL (2004) Functional diversity of ventral midbrain dopamine and GABAergic neurons. Mol Neurobiol 29:243–259.
Lim ST, Antonucci DE, Scannevin RH, Trimmer JS (2000) Anovel targeting signal for proximal clustering of the Kv2.1 K+ channel in hippocampal neurons. Neuron 25:385–397.
Liss B, Roeper J (2004) Correlating function and gene expression of individual basal ganglia neurons. Trends Neurosci 27:475– 481.
Liss B, Haeckel O, Wildmann J, Miki T, Seino S, Roeper J (2005) K-ATP
channels promote the differential degeneration of dopaminergic midbrain neurons. Nat Neurosci 8:1742–1751.
MacLean JN, Zhang Y, Johnson BR, Harris-Warrick RM (2003) Activity independent homeostasis in rhythmically active neurons. Neuron
37:109 –120.
Malin SA, Nerbonne JM (2002) Delayed rectifier K+ currents, IK, are encoded by Kv2 [alpha]-subunits and regulate tonic firing in mammalian sympathetic neurons. J Neurosci 22:10094 –10105.
Mee CJ, Pym EC, Moffat KG, Baines RA (2004) Regulation of neuronal
excitability through pumilio-dependent control of a sodium channel
gene. J Neurosci 24:8695– 8703.
Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misonou K, Anderson AE, Trimmer JS (2004) Regulation of ion channel localization and phosphorylation by neuronal activity. Nat Neurosci 7:711–718.
Misonou H, Mohapatra DP, Menegola M, Trimmer JS (2005) Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia. J Neurosci 25:11184 –11193.
Moore DJ, West AB, Dawson VL, Dawson TM (2005) Molecular pathophysiology of Parkinson’s disease. Annu Rev Neurosci 28:57– 87.
Murakoshi H, Trimmer JS (1999) Identification of the Kv2.1 K+ channel as a major component of the delayed rectifier K+ current in rat hippocampal neurons. J Neurosci 19:1728 –1735.
Nelson SB, Sugino K, Hempel CM (2006) The problem of neuronal cell
types: a physiological genomics approach. Trends Neurosci 29:339 –345.
Nicols CG (2006) KATP channels as molecular sensors of cellular metabolism. Nature 440:470–476.
Nusbaum MP, Blitz DM, Swensen AM, Wood D, Marder E (2001) The roles of co-transmission in neural network modulation. Trends Neurosci 24:146 –154.
Park K-S, Mohapatra DP, Misonou H, Trimmer JS (2006) Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science 313:976 –979.
Schulz DJ, Goaillard J-M, Marder E (2006) Variable channel expression in identified single and electrically coupled neurons in different animals. Nat Neurosci 9:356 –362.
Seamans JK, Yang CR (2004) The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog Neurobiol 74:1–58.
Sugino K, Hempel CM, Miller MN, Hattox AM, Shapiro P, Wu C, Huang ZJ, Nelson SB (2006) Molecular taxonomy of major neuronal classes in the adult mouse forebrain. Nat Neurosci 9:99 –107.
Swensen AM, Marder E (2001) Modulators with convergent cellular actions elicit distinct circuit outputs. J Neurosci 21:4050–4058.
Turrigiano GG, Nelson SB (2004) Homeostatic plasticity in the developing nervous system. Nat Rev Neurosci 5:97–107.