Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

A randomised factorial design clinical trial to investigate the impact of parenteral long acting oxytetracycline, foot trimming and flunixine meglumine on time to recovery from lameness and foot lesions in sheep lame with footrot

Tools
- Tools
+ Tools

Kaler, Jasmeet, Daniels, S. L. S., Wright, Jordan L. and Green, Laura E. (2010) A randomised factorial design clinical trial to investigate the impact of parenteral long acting oxytetracycline, foot trimming and flunixine meglumine on time to recovery from lameness and foot lesions in sheep lame with footrot. Journal of Veterinary Internal Medicine, 24 (2). pp. 420-425. doi:10.1111/j.1939-1676.2009.0450.x

[img] PDF (Article Main Text)
WRAP_Kaler_9877845-bs-191109-kaler_et_al._2009_clinical_trial_footrot-_r2-f.pdf - Requires a PDF viewer.

Download (225Kb)
[img] PDF (Blackwell Policy)
WRAP_Kaler_Blackwell_permission.pdf
Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer.

Download (277Kb)
Official URL: http://dx.doi.org/10.1111/j.1939-1676.2009.0450.x

Request Changes to record.

Abstract

Background: Internationally, foot trimming is used by most farmers and parenteral antibacterials by some, to treat sheep with footrot. Non steroidal anti-inflammatory drugs (NSAID) are sometimes used. No clinical trials have compared these treatments.
Objectives: To investigate the above treatments on time to recovery from lameness and foot 5 lesions in sheep with footrot.
Animals: 53 sheep with footrot on a commercial farm in England.
Methods: In a randomised factorial design, the sheep were allocated to treatment groups. The 8 treatments were oxytetracycline spray to all sheep (positive control) and one or more of: parenteral administration of long acting oxytetracycline, flunixine meglumine and foot trimming on day 1 or day 6 of diagnosis. Follow-up was for 15 days. Time to recovery from lameness and lesions was investigated with discrete- time survival models.
Results: There was significant association (p<0.05) between recovery from lameness and lesions. Sheep receiving antibacterials parenterally recovered faster from lameness (odds ratio (OR): 4.92 (1.20-20.10)) and lesions (OR: 5.11 (1.16-22.4)) than positive controls whereas sheep foot trimmed on day 1 (lameness- OR: 0.05 (0.005-0.51); lesions- OR: 0.06 (0.008-0.45)) or day 6 of diagnosis (lameness-OR: 0.07 (0.01-0.72); lesions- OR: 0.07 (0.01-0.56)) recovered slowly than positive controls. NSAID had no significant effect on recovery.
Conclusions and Clinical Importance: If foot trimming on day 1 or 6 of diagnosis was stopped and parenteral antibacterials were used, then over 1 million sheep/annum lame with footrot in the UK, would recover more rapidly with benefits to productivity. Globally, this figure would be 21 much higher.

Item Type: Journal Article
Subjects: S Agriculture > SF Animal culture
Divisions: Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH): Footrot in sheep -- Research, Sheep -- Infections -- Research, Veterinary medicine -- Research, Antibacterial agents, Anti-inflammatory agents
Journal or Publication Title: Journal of Veterinary Internal Medicine
Publisher: Wiley-Blackwell Publishing, Inc.
ISSN: 0891-6640
Official Date: March 2010
Dates:
DateEvent
March 2010Published
30 December 2009Available
10 November 2009Accepted
Volume: 24
Number: 2
Page Range: pp. 420-425
DOI: 10.1111/j.1939-1676.2009.0450.x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number: BBE01870X1 (BBSRC)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us