Outlaw, M. C. and Dimmock, N. J.. (1991) Insights into neutralization of animal viruses gained from study of influenza virus. Epidemiology and Infection, Vol.106 (No.2). pp. 205-220. ISSN 0950-2688

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Abstract

It has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process. This is probably because neutralization is a multifactorial phenomenon depending upon the nature of the virus itself, the particular antigenic site involved, the isotype of immunoglobulin and the ratio of virus to immunoglobulin (see below). Thus not only is it likely that neutralization of one virus will differ from another but that changing the circumstances of neutralization can change the mechanism itself. To give coherence to the topic we are concentrating this review on one virus, influenza type A which is itself well studied and reasonably well understood [1–3]. Reviews of the older literature can be found in references 4 to 7.

Item Type:	Journal Article
Subjects:	S Agriculture > SF Animal culture Q Science > QR Microbiology > QR355 Virology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Influenza viruses -- Research, Viral antibodies -- Research, Virus diseases -- Immunological aspects, Veterinary virology
Journal or Publication Title:	Epidemiology and Infection
Publisher:	Cambridge University Press
ISSN:	0950-2688
Date:	April 1991
Volume:	Vol.106
Number:	No.2
Page Range:	pp. 205-220
Identification Number:	10.1017/S0950268800048354
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Science and Engineering Research Council (Great Britain) (SERC), Wellcome Trust (London, England), Great Britain. Ministry of Defence (MoD)
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URI:	http://wrap.warwick.ac.uk/id/eprint/2674

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