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Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK

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Collins, K. R. and Easton, A. J. (Andrew J.). (1995) Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK. Epidemiology and Infection, Vol.114 (No.3). pp. 493-500. ISSN 0950-2688

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Official URL: http://dx.doi.org/10.1017/S0950268800052201

Abstract

The sequence variation in a 934 base-pair region of the gene encoding the haemagglutinin-neuraminidase of five human parainfluenza virus type 3 (HPIV3) isolates was determined together with that of a prototype UK strain. All of the clinical isolates were from the Manchester area of the UK and were obtained in 1990. 1991 and 1993. The gene segment was amplified by the polymerase chain reaction using HPIVB-specific oligonucleotide primers. The nucleotide homology of the strains was high, around 99% and specific differences in the UK sequences when compared with that of the US prototype strain were identified. In addition, a number of isolate-specific differences were seen. No correlation was detected between the observed nucleotide mutations and the year of isolation, which supports the hypothesis that HPIV3 shows cocirculation of a heterogeneous population of viruses rather than varying with time in a linear fashion. However, the data suggested that geographically-defined genetic lineages of HPIV3 may exist.

Item Type:

Journal Article

Subjects:

Q Science > QR Microbiology > QR355 Virology

Divisions:

Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)

Library of Congress Subject Headings (LCSH):

Influenza viruses -- Genetics, Polymerase chain reaction -- Diagnostic use, Nucleotides -- Analysis, Viruses -- Evolution -- England -- Manchester

Journal or Publication Title:

Epidemiology and Infection

Publisher:

Cambridge University Press

ISSN:

0950-2688

Official Date:

June 1995

Dates:

Date	Event
June 1995	Published

Volume:

Vol.114

Number:

No.3

Page Range:

pp. 493-500

Identification Number:

10.1017/S0950268800052201

Status:

Peer Reviewed

Access rights to Published version:

Open Access

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