The Library
Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring
Tools
Tools
Tools
Zammit, Stanley, Thomas, Kate, Thompson, Andrew D., Horwood, Jeremy, Menezes, Paulo, Gunnell, David, Hollis, Chris, Wolke, Dieter, Lewis, Glyn and Harrison, Glynn (2009) Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring. British Journal of Psychiatry, 195 (4). pp. 294-300. doi:10.1192/bjp.bp.108.062471 ISSN 0007-1250.
![[img]](https://wrap.warwick.ac.uk/style/images/fileicons/text.png) |
Text
WRAP_Wolke_SU_in_pregnancy__PLIKS_10-11-08_notrack.pdf Download (233Kb) |
Official URL: http://dx.doi.org/10.1192/bjp.bp.108.062471
Abstract
Background
Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology.
Aims
To examine whether maternal use of tobacco, cannabis or alcohol during pregnancy increases risk of offspring psychotic symptoms.
Method
A longitudinal study of 6356 adolescents, age 12, who completed a semi-structured interview for psychotic symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort.
Results
Frequency of maternal tobacco use during pregnancy was associated with increased risk of suspected or definite psychotic symptoms (adjusted odds ratio 1.20, 95% CI 1.05–1.37, P = 0.007). Maternal alcohol use showed a non-linear association with psychotic symptoms, with this effect almost exclusively in the offspring of women drinking >21 units weekly. Maternal cannabis use was not associated with psychotic symptoms. Results for paternal smoking during pregnancy and maternal smoking post-pregnancy lend some support for a causal effect of tobacco exposure in utero on development of psychotic experiences.
Conclusions
These findings indicate that risk factors for development of non-clinical psychotic experiences may operate during early development. Future studies of how in utero exposure to tobacco affects cerebral development and function may lead to increased understanding of the pathogenesis of psychotic phenomena.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RG Gynecology and obstetrics B Philosophy. Psychology. Religion > BF Psychology |
||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
| Library of Congress Subject Headings (LCSH): | Avon Longitudinal Study of Parents and Children, Substance abuse in pregnancy -- Great Britain, Pregnant women -- Tobacco use, Adolescent psychopathology -- Research, Fetus -- Development | ||||
| Journal or Publication Title: | British Journal of Psychiatry | ||||
| Publisher: | Royal College of Psychiatrists | ||||
| ISSN: | 0007-1250 | ||||
| Official Date: | October 2009 | ||||
| Dates: |
|
||||
| Volume: | 195 | ||||
| Number: | 4 | ||||
| Page Range: | pp. 294-300 | ||||
| DOI: | 10.1192/bjp.bp.108.062471 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Funder: | Wellcome Trust (London, England), Wales. Welsh Assembly Government | ||||
| Grant number: | GR072043MA (Wellcome) |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
