Miller, Michelle A., Kandala, Ngianga-Bakwin, Kivimäki, Mika, Kumari, Meena, Brunner, Eric, Lowe, G. D. O., Marmot, M. G. and Cappuccio, Francesco (2009) Gender differences in the cross-sectional relationships between sleep duration and markers of inflammation : Whitehall II study. Sleep, Vol.32 (No.7). pp. 857-864.

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Abstract

Objective: To examine the relationships between sleep and inflammatory markers because these may be important in the development of cardiovascular disease.

Methods and Results: The relationship between self-reported sleep duration and intedeukin-6 (IL-6) (n = 4642) and high-sensitivity C-reactive protein (hs-CRP) (n = 4677) was examined in individuals from the Whitehall 11 study. Following multiple adjustments, there were no overall linear or nonlinear trends between sleep duration and IL-6. However, in women but not men (interaction P < 0.05), levels of IL-6 tended to be lower in individuals who slept 8 hours (11% [95% confidence interval 4 to 171) as compared to 7 hours. With hs-CRP, in the adjusted model, there was no association between hs-CRP and sleep duration in men. However, there was a significant nonlinear association in women, the level of hs-CRP being significantly higher in women short sleepers (5 hours or less) after multiple adjustments (P = 0.04) (interaction P < 0.05).

Conclusions: No significant variation in inflammatory markers with sleep duration was observed in men. By contrast, both IL-6 and hsCRP levels varied with sleep duration in women. The observed pattern of variation was different according to the inflammatory marker observed. Further longitudinal studies are required to fully investigate possible temporal relationships between short sleep and markers of inflammation.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) > Warwick Evidence Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Cardiovascular system -- Diseases, Inflammation, Sleep, Sleep deprivation -- Sex differences
Journal or Publication Title:	Sleep
Publisher:	American Academy of Sleep Medicine
ISSN:	0161-8105
Official Date:	1 July 2009
Dates:	Date Event 1 July 2009 Published
Volume:	Vol.32
Number:	No.7
Number of Pages:	8
Page Range:	pp. 857-864
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	University of Warwick, Wingate Foundation, NHS Workforce

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