Meta-analysis of the effects of flaxseed interventions on blood lipids
Pan, An, Yu, Danxia, Demark-Wahnefried, Wendy, Franco, Oscar H. and Lin, Xu. (2009) Meta-analysis of the effects of flaxseed interventions on blood lipids. American Journal of Clinical Nutrition, Vol.90 (No.2). pp. 288-297. ISSN 0002-9165Full text not available from this repository.
Official URL: http://dx.doi.org/10.3945/ajcn.2009.27469
Background: Several clinical trials have investigated the effects of flaxseed and flaxseed-derived products (flaxseed oil or lignans) on blood lipids; however, the findings have been inconsistent.
Objective: We aimed to identify and quantify the effectiveness of flaxseed and its derivatives on blood lipid profiles.
Design: A comprehensive literature search was performed on the basis of English reports of randomized controlled trials of flaxseed or its derivatives on lipid profiles in adults, which were published from January 1990 to October 2008. Attempts also were made to access unpublished data. Study quality was assessed by using the Jadad score, and a meta-analysis was conducted.
Results: Twenty-eight studies were included. Flaxseed interventions reduced total and LDL cholesterol by 0.10 mmol/L (95% CI: -0.20, 0.00 mmol/L) and 0.08 mmol/L (95% CI: -0.16, 0.00 mmol/L), respectively; significant reductions were observed with whole flaxseed (-0.21 and -0.16 mmol/L, respectively) and lignan (-0.28 and -0.16 mmol/L, respectively) supplements but not with flaxseed oil. The cholesterol-lowering effects were more apparent in females (particularly postmenopausal women), individuals with high initial cholesterol concentrations, and studies with higher Jadad scores. No significant changes were found in the concentrations of HDL cholesterol and triglycerides.
Conclusions: Flaxseed significantly reduced circulating total and LDL-cholesterol concentrations, but the changes were dependent on the type of intervention, sex, and initial lipid profiles of the subjects. Further studies are needed to determine the efficiency of flaxseed on lipid profiles in men and premenopausal women and to explore its potential benefits on other cardiometabolic risk factors and prevention of cardiovascular disease. Am J Clin Nutr 2009;90:288-97.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RA Public aspects of medicine|
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||American Journal of Clinical Nutrition|
|Publisher:||American Society for Nutrition|
|Official Date:||1 August 2009|
|Number of Pages:||10|
|Page Range:||pp. 288-297|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Ministry of Science and Technology of China|
|Grant number:||KSCX1-YW-02 and KSCX1-YWR116, SIBS2008006, 2008DFA31960|
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