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Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates

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Parajo, Yolanda, Malina, J. (Jaroslav), Meistermann, Isabelle, Clarkson, Guy J., Pascu, Mirela, Rodger, Alison, Hannon, M. J. (Michael J.) and Lincoln, Per. (2009) Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates. Dalton Transactions (No.25). pp. 4868-4874. ISSN 1477-9226

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Abstract

Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH2. The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Linear dichroism, Molecular recognition, Nucleic acids, DNA-binding proteins, Supramolecular chemistry, Metal complexes, Iron
Journal or Publication Title: Dalton Transactions
Publisher: Royal Society of Chemistry
ISSN: 1477-9226
Official Date: 7 July 2009
Number: No.25
Number of Pages: 7
Page Range: pp. 4868-4874
Identification Number: 10.1039/b822039e
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: European Union (EU), University of Warwick, European Cooperation in the Field of Scientific and Technical Research (Organization) (COST)
Grant number: HPRN-CT-2002-00175 (EU), WG D20/0010/02 (COST)
References:

1 S. Neidle, Nucleic acid structure and recognition, Oxford University
Press, Oxford, 2002.
2 S. J. Lippard, J. M. Berg, Principles of Bioinorganic Chemistry,
University Science Books, Mill Valley, CA, 1994.
3 J. B. Chaires, Curr. Opin. Struct. Biol., 1998, 8, 314.
4 M. J. Hannon, Chem. Soc. Rev., 2007, 36, 280.
5 P. B. Dervan and B. S. Edelson, Curr. Opin. Struct. Biol., 2003, 13, 284.
6 P. B. Dervan, Bioorg. Med. Chem., 2001, 9, 2215.
7 B. C. Baguley, Anti-Cancer Drug Des., 1991, 6, 1.
8 P. Lincoln and B. Nord´en, J. Phys. Chem. B, 1998, 102, 9583.
9 P. B. Glover, P. R. Ashton, L. J. Childs, A. Rodger, M. Kercher, R. M.
Williams, L. De Cola and Z. Pikramenou, J. Am. Chem. Soc., 2003,
125, 9918.
10 P. Nordell, F. Westerlund, L. M. Wilhelmsson, B. Nord´en and P.
Lincoln, Angew. Chem., Int. Ed., 2007, 46, 2203.
11 J. M. Berg, J. L. Tymoczko, L. Stryer, Biochemistry, 5th edn, Freeman,
New York, 2002.
12 C. Branden, J. Tooze, Introduction to Protein Structure, 2nd edn,
Garland, New York, 1999.
13 R. E. Dickerson, Nucleic Acids Res., 1998, 26, 1906.
14 M. J. Hannon, V. Moreno, M. J. Prieto, E. Moldrheim, E. Sletten, I.
Meistermann, C. J. Isaac, K. J. Sanders and A. Rodger, Angew. Chem.,
2001, 113, 903.
15 M. J. Hannon, V. Moreno, M. J. Prieto, E. Moldrheim, E. Sletten, I.
Meistermann, C. J. Isaac, K. J. Sanders and A. Rodger, Angew. Chem.,
Int. Ed., 2001, 40, 880.
16 I. Meistermann, V. Moreno, M. J. Prieto, E. Moldrheim, E. Sletten,
S. Khalid, M. Rodger, J. Peberdy, C. J. Isaac, A. Rodger and M. J.
Hannon, Proc. Natl. Acad. Sci. U. S. A., 2002, 99, 5069.
17 E. Moldrheim, M. J. Hannon, I. Meistermann, A. Rodger and E.
Sletten, J. Biol. Inorg. Chem., 2002, 7, 770.
18 M. J. Hannon and A. Rodger, Pharmaceutical Visions, 2002, autumn
issue 14.
19 J. M. C. Kerckhoffs, J. C. Peberdy, I. Meistermann, L. J. Childs, C. J.
Isaac, C. R. Pearmund, V. Reudegger, S. Khalid, N. W. Alcock, M. J.
Hannon and A. Rodger, Dalton Trans., 2007, 734.
20 A. Oleksi, A. G. Blanco, R. Boer, I. Uson, J. Aymani, A. Rodger,M. J.
Hannon and M. Coll, Angew. Chem., Int. Ed., 2006, 45, 1227.
21 L. Cerasino, M. J. Hannon and E. Sletten, Inorg. Chem., 2007, 46,
6245.
22 A. Lavalette, H. Hamblin, A. Marsh, D. M. Haddleton and M. J.
Hannon, Chem. Commun., 2002, 3040.
23 J.-B. LePecq and C. Paoletti, J. Mol. Biol., 1967, 27, 87.
24 A. Rodger, B. Norden, Circular and Linear Dichroism, Oxford University
Press, Oxford, 1997.
25 SMART user’s manual, Siemens Industrial Automation Inc.,Madison,
WI, 1994.
26 J. Cosier and A. M. Glazer, J. Appl. Crystallogr., 1986, 19, 105.
27 G. M. Sheldrick, Acta Crystallogr., Sect. A: Found. Crystallogr., 1990,
46, 4.
28 A. Rodger, Meth. Enzymol., 1993, 226, 232.
29 B. Nord´en, M. Kubista and T. Kurucsev, Q. Rev. Biophys., 1992, 25,
51.
30 B. Nord´en and T. Kurucsev, J. Mol. Recog., 1994, 7, 141.
URI: http://wrap.warwick.ac.uk/id/eprint/27760

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