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Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates

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Parajo, Yolanda, Malina, J. (Jaroslav), Meistermann, Isabelle, Clarkson, Guy J., Pascu, Mirela, Rodger, Alison, Hannon, M. J. (Michael J.) and Lincoln, Per. (2009) Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates. Dalton Transactions (No.25). pp. 4868-4874. ISSN 1477-9226

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Official URL: http://dx.doi.org/10.1039/b822039e

Abstract

Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH2. The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand.

Item Type:

Journal Article

Subjects:

Q Science > QD Chemistry
Q Science > QP Physiology

Divisions:

Faculty of Science > Chemistry

Library of Congress Subject Headings (LCSH):

Linear dichroism, Molecular recognition, Nucleic acids, DNA-binding proteins, Supramolecular chemistry, Metal complexes, Iron

Journal or Publication Title:

Dalton Transactions

Publisher:

Royal Society of Chemistry

ISSN:

1477-9226

Official Date:

7 July 2009

Dates:

Date	Event
7 July 2009	Published

Number:

No.25

Number of Pages:

Page Range:

pp. 4868-4874

Identification Number:

10.1039/b822039e

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

European Union (EU), University of Warwick, European Cooperation in the Field of Scientific and Technical Research (Organization) (COST)

Grant number:

HPRN-CT-2002-00175 (EU), WG D20/0010/02 (COST)

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