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Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates
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Parajo, Yolanda, Malina, J. (Jaroslav), Meistermann, Isabelle, Clarkson, Guy J., Pascu, Mirela, Rodger, Alison, Hannon, M. J. (Michael J.) and Lincoln, Per (2009) Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates. Dalton Transactions (No.25). pp. 4868-4874. doi:10.1039/b822039e
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Official URL: http://dx.doi.org/10.1039/b822039e
Abstract
Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH2. The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Linear dichroism, Molecular recognition, Nucleic acids, DNA-binding proteins, Supramolecular chemistry, Metal complexes, Iron | ||||
| Journal or Publication Title: | Dalton Transactions | ||||
| Publisher: | Royal Society of Chemistry | ||||
| ISSN: | 1477-9226 | ||||
| Official Date: | 7 July 2009 | ||||
| Dates: |
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| Number: | No.25 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 4868-4874 | ||||
| DOI: | 10.1039/b822039e | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | European Union (EU), University of Warwick, European Cooperation in the Field of Scientific and Technical Research (Organization) (COST) | ||||
| Grant number: | HPRN-CT-2002-00175 (EU), WG D20/0010/02 (COST) |
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