Lee, Juin-Der, Su, Hong-Ren, Cheng, Philip E., Liou, Michelle, Aston, John A. D., Tsai, Arthur C. and Chen, Cheng-Yu. (2009) MR image segmentation using a power transformation approach. IEEE Transactions on Medical Imaging, Vol.28 (No.6). pp. 894-905. ISSN 0278-0062

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Abstract

This study proposes a segmentation method for brain MR images using a distribution transformation approach. The method extends traditional Gaussian mixtures expectation-maximization segmentation to a power transformed version of mixed intensity distributions, which includes Gaussian mixtures as a special case. As MR intensities tend to exhibit non-Gaussianity due to partial volume effects, the proposed method is designed to fit non-Gaussian tissue intensity distributions. One advantage of the method is that it is intuitively appealing and computationally simple. To avoid performance degradation caused by intensity inhomogeneity, different methods for correcting bias fields were applied prior to image segmentation, and their correction effects on the segmentation results were examined in the empirical study. The partitions of brain tissues (i.e., gray and white matter) resulting from the method were validated and evaluated against manual segmentation results based on 38 real T1-weighted image volumes from the internet brain segmentation repository, and 18 simulated image volumes from BrainWeb. The Jaccard and Dice similarity indexes were computed to evaluate the performance of the proposed approach relative to the expert segmentations. Empirical results suggested that the proposed segmentation method yielded higher similarity measures for both gray matter and white matter as compared with those based on the traditional segmentation using the Gaussian mixtures approach.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software R Medicine T Technology > TK Electrical engineering. Electronics Nuclear engineering T Technology > TR Photography
Divisions:	Faculty of Science > Statistics
Journal or Publication Title:	IEEE Transactions on Medical Imaging
Publisher:	IEEE
ISSN:	0278-0062
Official Date:	June 2009
Volume:	Vol.28
Number:	No.6
Number of Pages:	12
Page Range:	pp. 894-905
Identification Number:	10.1109/TMI.2009.2012896
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/27795

Data sourced from Thomson Reuters' Web of Knowledge

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