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Administration of a new diabetes-specific enteral formula results in an improved 24 h glucose profile in type 2 diabetic patients
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Ceriello, Antonio, Lansink, Mirian, Rouws, Carlette H. F. C., van Laere, Katrien M. J. and Frost, Gary S. (2009) Administration of a new diabetes-specific enteral formula results in an improved 24 h glucose profile in type 2 diabetic patients. Diabetes Research and Clinical Practice, Vol.84 (No.3). pp. 259-266. doi:10.1016/j.diabres.2009.02.013 ISSN 0168-8227.
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Official URL: http://dx.doi.org/10.1016/j.diabres.2009.02.013
Abstract
Aims: Study the effect of several boluses of a new diabetes-specific formula (DSF) during the day on 24 h glucose profile.
Methods: In this randomized, controlled, double-blind, cross-over study 12 ambulatory type 2 diabetic patients were included. Subjects received a new DSF and an isocaloric standard fibre-containing formula (SF) while continuing their anti-diabetic medication. Subjects received 100% of their calculated daily energy requirements as bolus feeding every 3 h (5 times/day, starting at 8.00 a.m. +/- 1 h).
Results: Glucose profiles were significantly better after administration of DSF compared with SF determined as mean glucose concentration (+/- SEM) (8.7 +/- 0.5 versus 9.6 +/- 0.6 mmol/L, p < 0.05 during 24 h; 9.4 +/- 0.6 versus 10.7 +/- 0.6 mmol/L, p < 0.001 during daytime) or as incremental area under the curve during daytime (-44%; p < 0.05). Subjects receiving DSF experienced less hyperglycaemic time over 24 h (-26%; p < 0.05) and during daytime (-30%; p < 0.05). Furthermore, lower individual and mean (delta) peak glucose levels were found (p < 0.05). No clinically relevant differences in gastrointestinal tolerance were observed.
Conclusions: Using DSF resulted in significantly better 24 h and postprandial glucose profiles than fibre-containing SF after bolus administration and may therefore help to improve glycaemic control in diabetic patients. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Diabetes Research and Clinical Practice | ||||
| Publisher: | Elsevier Ireland Ltd | ||||
| ISSN: | 0168-8227 | ||||
| Official Date: | June 2009 | ||||
| Dates: |
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| Volume: | Vol.84 | ||||
| Number: | No.3 | ||||
| Number of Pages: | 8 | ||||
| Page Range: | pp. 259-266 | ||||
| DOI: | 10.1016/j.diabres.2009.02.013 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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