Ceriello, Antonio, Lansink, Mirian, Rouws, Carlette H. F. C., van Laere, Katrien M. J. and Frost, Gary S.. (2009) Administration of a new diabetes-specific enteral formula results in an improved 24 h glucose profile in type 2 diabetic patients. Diabetes Research and Clinical Practice, Vol.84 (No.3). pp. 259-266. ISSN 0168-8227

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Abstract

Aims: Study the effect of several boluses of a new diabetes-specific formula (DSF) during the day on 24 h glucose profile. Methods: In this randomized, controlled, double-blind, cross-over study 12 ambulatory type 2 diabetic patients were included. Subjects received a new DSF and an isocaloric standard fibre-containing formula (SF) while continuing their anti-diabetic medication. Subjects received 100% of their calculated daily energy requirements as bolus feeding every 3 h (5 times/day, starting at 8.00 a.m. +/- 1 h). Results: Glucose profiles were significantly better after administration of DSF compared with SF determined as mean glucose concentration (+/- SEM) (8.7 +/- 0.5 versus 9.6 +/- 0.6 mmol/L, p < 0.05 during 24 h; 9.4 +/- 0.6 versus 10.7 +/- 0.6 mmol/L, p < 0.001 during daytime) or as incremental area under the curve during daytime (-44%; p < 0.05). Subjects receiving DSF experienced less hyperglycaemic time over 24 h (-26%; p < 0.05) and during daytime (-30%; p < 0.05). Furthermore, lower individual and mean (delta) peak glucose levels were found (p < 0.05). No clinically relevant differences in gastrointestinal tolerance were observed. Conclusions: Using DSF resulted in significantly better 24 h and postprandial glucose profiles than fibre-containing SF after bolus administration and may therefore help to improve glycaemic control in diabetic patients. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Diabetes Research and Clinical Practice
Publisher:	Elsevier Ireland Ltd
ISSN:	0168-8227
Date:	June 2009
Volume:	Vol.84
Number:	No.3
Number of Pages:	8
Page Range:	pp. 259-266
Identification Number:	10.1016/j.diabres.2009.02.013
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/27802

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