Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older Chinese people
Yu, Zhijie, Ye, Xingwang, Wang, Jing, Qi, Qibin, Franco, Oscar H., Rennie, Kirsten L., Pan, An, Li, Huaixing, Liu, Yong, Hu, Frank B. and Lin, Xu (2009) Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older Chinese people. In: 68th Annual Meeting of the American Diabetes Association, San Francisco, CA, June 06-10, 2008. Published in: Circulation, Vol.119 (No.23). pp. 2969-2977.Full text not available from this repository.
Official URL: http://dx.doi.org/10.1161/CIRCULATIONAHA.108.83357...
Background-Inflammatory factors, adipocytokines, and the metabolic syndrome are important determinants of cardiometabolic disease. It remains unclear how physical activity is related to these risk factors. Our objective was to investigate single and joint associations of physical activity with inflammatory factors, adipocytokines, and the metabolic syndrome among middle-aged and older Chinese people.
Methods and Results-A total of 3289 individuals ( 1458 men, 1831 women) 50 to 70 years of age participated in a population-based cross-sectional survey in Beijing and Shanghai, China. Levels of total physical activity were assessed with the International Physical Activity Questionnaire. High-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha receptor 2, adiponectin, and retinol-binding protein 4 were measured. The metabolic syndrome was defined using the updated National Cholesterol Education Program/Adult Treatment Panel III criteria for Asian Americans. Plasma concentrations of high-sensitivity C-reactive protein were 1.58, 1.74, and 1.27 mg/ L (P=0.0138) and of adiponectin were 16.12, 16.20, and 17.21 mg/ L (P=0.0078) among individuals with low, medium, and high levels of total physical activity, respectively, with adjustment for potential confounders. In the multivariable-adjusted logistic regression analyses, participants with higher levels of total physical activity had a lower risk of having the metabolic syndrome ( odds ratio, 0.68; 95% confidence interval, 0.54 to 0.85; P for trend=0.001) compared with those with lower levels.
Conclusions-Being physically active is associated with a better profile of inflammatory factors and adipocytokines and a reduced risk of having the metabolic syndrome among Chinese people. ( Circulation. 2009; 119: 2969-2977.)
|Item Type:||Conference Item (Paper)|
|Subjects:||Q Science > QM Human anatomy
R Medicine > RB Pathology
R Medicine > RC Internal medicine
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Circulation|
|Publisher:||American Heart Association|
|Official Date:||16 June 2009|
|Number of Pages:||11|
|Page Range:||pp. 2969-2977|
|Access rights to Published version:||Restricted or Subscription Access|
|Conference Paper Type:||Paper|
|Title of Event:||68th Annual Meeting of the American Diabetes Association|
|Type of Event:||Conference|
|Location of Event:||San Francisco, CA|
|Date(s) of Event:||June 06-10, 2008|
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