Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds : the ALSPAC cohort
Thomas, Kate, Harrison, Glynn, Zammit, Stanley, Lewis, Glyn, Horwood, Jeremy, Heron, Jon, Hollis, Chris, Wolke, Dieter, Thompson, Andrew D. and Gunnell, David. (2009) Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds : the ALSPAC cohort. British Journal of Psychiatry, 194 (6). pp. 521-526. ISSN 0007-1250Full text not available from this repository.
Official URL: http://dx.doi.org/10.1192/bjp.bp.108.051730
Previous studies have suggested that impaired fetal and childhood growth are associated with an increased risk of schizophrenia, but the association of pre-adult growth with non-clinical psychotic symptoms (psychosis-like symptoms) in children is not known.
To explore the associations of body size at birth and age 7.5 years with childhood psychosis-like symptoms.
Prospective cohort of children followed up from birth to age 12: the ALSPAC cohort.
Data on 6000 singleton infants born after 37 weeks of gestation. A one standard deviation increase in birth weight was associated with an 18% reduction in the risk of definite psychosis-like symptoms after adjusting for age and gestation (Odds ratio (OR)=0.82, 95% CI=0.73-0.92, P=0.001). This association was partly confounded by maternal anthropometry, smoking during pregnancy, socioeconomic status and IQ. A similar association was seen for birth length and psychosis-like symptoms, which disappeared after controlling for birth weight. There was little evidence for an association of 7-year height or adiposity with psychosis-like symptoms.
Measures of impaired fetal, but not childhood, growth are associated with an increased risk of psychosis-like symptoms in 12-year-olds.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RJ Pediatrics
|Divisions:||Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing
Faculty of Science > Psychology
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Body mass index, Schizoaffective disorders, Cohort analysis, Child development|
|Journal or Publication Title:||British Journal of Psychiatry|
|Publisher:||Royal College of Psychiatrists|
|Official Date:||June 2009|
|Number of Pages:||6|
|Page Range:||pp. 521-526|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC), University of Bristol|
1 Poulton R, Caspi A, Moffitt TE, Cannon M, Murray R, Harrington H. Children’s
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