Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds : the ALSPAC cohort
Thomas, Kate, 1972-, Harrison, Glynn, Zammit, Stanley, Lewis, Glyn, Horwood, Jeremy, Heron, Jon, Hollis, Chris, Wolke, Dieter, Thompson, Andrew, 1932- and Gunnell, David. (2009) Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds : the ALSPAC cohort. British Journal of Psychiatry, Vol.194 (No.6). pp. 521-526. ISSN 0007-1250Full text not available from this repository.
Official URL: http://dx.doi.org/10.1192/bjp.bp.108.051730
Previous studies have suggested that impaired fetal and childhood growth are associated with an increased risk of schizophrenia, but the association of pre-adult growth with non-clinical psychotic symptoms (psychosis-like symptoms) in children is not known.
To explore the associations of body size at birth and age 7.5 years with childhood psychosis-like symptoms.
Prospective cohort of children followed up from birth to age 12: the ALSPAC cohort.
Data on 6000 singleton infants born after 37 weeks of gestation. A one standard deviation increase in birth weight was associated with an 18% reduction in the risk of definite psychosis-like symptoms after adjusting for age and gestation (Odds ratio (OR)=0.82, 95% CI=0.73-0.92, P=0.001). This association was partly confounded by maternal anthropometry, smoking during pregnancy, socioeconomic status and IQ. A similar association was seen for birth length and psychosis-like symptoms, which disappeared after controlling for birth weight. There was little evidence for an association of 7-year height or adiposity with psychosis-like symptoms.
Measures of impaired fetal, but not childhood, growth are associated with an increased risk of psychosis-like symptoms in 12-year-olds.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RJ Pediatrics
|Divisions:||Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing
Faculty of Science > Psychology
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Body mass index, Schizoaffective disorders, Cohort analysis, Child development|
|Journal or Publication Title:||British Journal of Psychiatry|
|Publisher:||Royal College of Psychiatrists|
|Official Date:||June 2009|
|Number of Pages:||6|
|Page Range:||pp. 521-526|
|Funder:||Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC), University of Bristol|
1 Poulton R, Caspi A, Moffitt TE, Cannon M, Murray R, Harrington H. Children’s
Actions (login required)