Thomas, Kate, 1972-, Harrison, Glynn, Zammit, Stanley, Lewis, Glyn, Horwood, Jeremy, Heron, Jon, Hollis, Chris, Wolke, Dieter, Thompson, Andrew, 1932- and Gunnell, David. (2009) Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds : the ALSPAC cohort. British Journal of Psychiatry, Vol.194 (No.6). pp. 521-526. ISSN 0007-1250

Full text not available from this repository.

Abstract

Background: Previous studies have suggested that impaired fetal and childhood growth are associated with an increased risk of schizophrenia, but the association of pre-adult growth with non-clinical psychotic symptoms (psychosis-like symptoms) in children is not known. Aims: To explore the associations of body size at birth and age 7.5 years with childhood psychosis-like symptoms. Method: Prospective cohort of children followed up from birth to age 12: the ALSPAC cohort. Results: Data on 6000 singleton infants born after 37 weeks of gestation. A one standard deviation increase in birth weight was associated with an 18% reduction in the risk of definite psychosis-like symptoms after adjusting for age and gestation (Odds ratio (OR)=0.82, 95% CI=0.73-0.92, P=0.001). This association was partly confounded by maternal anthropometry, smoking during pregnancy, socioeconomic status and IQ. A similar association was seen for birth length and psychosis-like symptoms, which disappeared after controlling for birth weight. There was little evidence for an association of 7-year height or adiposity with psychosis-like symptoms. Conclusions: Measures of impaired fetal, but not childhood, growth are associated with an increased risk of psychosis-like symptoms in 12-year-olds.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RJ Pediatrics
Divisions:	Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing Faculty of Science > Psychology
Library of Congress Subject Headings (LCSH):	Body mass index, Schizoaffective disorders, Cohort analysis, Child development
Journal or Publication Title:	British Journal of Psychiatry
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Date:	June 2009
Volume:	Vol.194
Number:	No.6
Number of Pages:	6
Page Range:	pp. 521-526
Identification Number:	10.1192/bjp.bp.108.051730
Status:	Peer Reviewed
Publication Status:	Published
Funder:	Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC), University of Bristol
Grant number:	072043
References:	1 Poulton R, Caspi A, Moffitt TE, Cannon M, Murray R, Harrington H. Children’s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch Gen Psychiatry 2000; 57: 1053–8. 2 Johns LC, Cannon M, Singleton N, Murray RM, Farrell M, Brugha T, et al. Prevalence and correlates of self-reported psychotic symptoms in the British population. Br J Psychiatry 2004; 185: 298–305. 3 Van Os J, Hanssen M, Bijl RV, Vollebergh W. Prevalence of psychotic disorder and community level of psychotic symptoms: an urban–rural comparison. Arch Gen Psychiatry 2001; 58: 663–8. 4 Hanssen M, Bak M, Bijl R, Vollebergh W, van OJ. The incidence and outcome of subclinical psychotic experiences in the general population. Br J Clin Psychol 2005; 44: 181–91. 5 Horwood J, Salvi G, Thomas K, Duffy L, Gunnell D, Hollis C, et al. IQ and nonclinical psychotic symptoms in 12-year-olds: results from the ALSPAC birth cohort. Br J Psychiatry 2008; 193: 185–91. 6 Cannon M, Caspi A, Moffitt TE, Harrington H, Taylor A, Murray RM, et al. Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort. Arch Gen Psychiatry 2002; 59: 449–56. 7 Gunnell D, Harrison G, Whitley E, Lewis G, Tynelius P, Rasmussen F. The association of fetal and childhood growth with risk of schizophrenia. Cohort study of 720,000 Swedish men and women. Schizophr Res 2005; 79: 315–22. 8 Wahlbeck K, Forsen T, Osmond C, Barker DJ, Eriksson JG. Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood. Arch Gen Psychiatry 2001; 58: 48–52. 9 Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: an historical and meta-analytic review. Am J Psychiatry 2002; 159: 1080–92. 10 Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987; 44: 660–9. 11 Golding J, Pembrey M, Jones R, ALSPAC study team. ALSPAC – the Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatr Perinat Epidemiology 2001; 15: 74–87. 12 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM–IV). APA, 1994. 13 World Health Organization. International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD–10) (2nd edn). WHO, 2005. 14 Cameron N. The methods of auxological anthropometry. In Human Growth. A Comprehensive Treatise (3rd edn) (ed F Falkner): 3–46. Plenum Press, 1986. 15 Office of Population Censuses and Surveys. Standard Occupational Classification. HMSO, 1991. 16 Wechsler D, Golombok S, Rust J. Wechsler Intelligence Scale for Children (3rd edn) (WISC–III–UK). Psychological Corporation, 1992. 17 Richards M, Hardy R, Kuh D, Wadsworth ME. Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study. BMJ 2001; 322: 199–203. 18 David AS, Malmberg A, Brandt L, Allebeck P, Lewis G. IQ and risk for schizophrenia: a population-based cohort study. Psychol Med 1997; 27: 1311–23. 19 Gunnell D, Harrison G, Rasmussen F, Fouskakis D, Tynelius P. Associations between premorbid intellectual performance, early-life exposures and earlyonset schizophrenia. Cohort study. Br J Psychiatry 2003; 181: 298–305. 20 Phillips AN, Davey Smith G. How independent are ‘independent’ effects? Relative risk estimation when correlated exposures are measured imprecisely. J Clin Epidemiol 1991; 44: 1223–31. 21 Callaway LK, McIntyre HD, O’Callaghan M, Williams GM, Najman JM, Lawlor DA. The association of hypertensive disorders of pregnancy with weight gain over the subsequent 21 years: findings from a prospective cohort study. Am J Epidemiol 2007; 166: 421–8. 22 Plewis I, Calderwoof L, Hawkes D, Nathan G. National Child Development Study and 1970 British Cohort Study Technical Report: Changes in the NCDS and BCS70 populations and samples over time. Centre for Longitudinal Studies, Institute of Education, 2004. 23 Gillberg C. Infantile autism and other childhood psychoses in a Swedish urban region. Epidemiological aspects. J Child Psychol Psychiatry 1984; 25: 35–43. 24 Wiles NJ, Peters TJ, Heron J, Gunnell D, Emond A, Lewis G. Fetal growth and childhood behavioral problems: results from the ALSPAC cohort. Am J Epidemiol 2006; 163: 829–37. 25 Zammit S, Rasmussen F, Farahmand B, Gunnell D, Lewis G, Tynelius P, et al. Height and body mass index in young adulthood and risk of schizophrenia: a longitudinal study of 1 347 520 Swedish men. Acta Psychiatr Scand 2007; 116: 378–85. 26 Weiser M, Knobler H, Lubin G, Nahon D, Kravitz E, Caspi A, et al. Body mass index and future schizophrenia in Israeli male adolescents. J Clin Psychiatry 2004; 65: 1546–9. 27 Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999; 122: 593–624. 28 Zammit S, Horwood J, Thompson A, Thomas K, Menezes P, Gunnell D, et al. Investigating if psychosis-like symptoms (PLIKS) are associated with family history of schizophrenia or paternal age in the ALSPAC birth cohort. Schizophr Res 2008; 104: 279–86. 29 Zammit S, Odd D, Horwood J, Thompson A, Thomas K, Menezes P et al. Investigating whether adverse prenatal and perinatal events are associated with non-clinical psychotic symptoms at age 12 years in the ALSPAC birth cohort. Psychol Med 2009; 12 February: doi: 10.1017/ S0033291708005126.
URI:	http://wrap.warwick.ac.uk/id/eprint/27805

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item