Commane, Daniel M., Arasaradnam, Ramesh P., Mills, Sarah, Mathers, John C. and Bradburn, Mike. (2009) Diet, ageing and genetic factors in the pathogenesis of diverticular disease. World Journal of Gastroenterology, Vol.15 (No.20). pp. 2479-2488. ISSN 1007-9327

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Abstract

Diverticular disease (DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK. This high prevalence ranks it as one of the most common bowel disorders in western nations. The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum. Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality. In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressure-induced damage to the colon wall amongst those with a low intake of dietary fiber. In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development. We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal. We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease. (C) 2009 The WJG Press and Baishideng. All rights reserved.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	World Journal of Gastroenterology
Publisher:	W J G Press
ISSN:	1007-9327
Official Date:	28 May 2009
Volume:	Vol.15
Number:	No.20
Number of Pages:	10
Page Range:	pp. 2479-2488
Identification Number:	10.3748/wjg.15.2479
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/27814

Data sourced from Thomson Reuters' Web of Knowledge

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