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Antimicrobial activity of Coniothyrium minitans and its macrolide antibiotic macrosphelide A
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Tomprefa, N., McQuilken, M. P., Hill, R. A. and Whipps, J. M.. (2009) Antimicrobial activity of Coniothyrium minitans and its macrolide antibiotic macrosphelide A. Journal of Applied Microbiology, Vol.106 (No.6). pp. 2048-2056. ISSN 1364-5072
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Official URL: http://dx.doi.org/10.1111/j.1365-2672.2009.04174.x
Abstract
Aims: Assessment of antimicrobial activity of the mycoparasite Coniothyrium minitans and its macrolide antibiotic macrosphelide A. Methods and Results: Thirteen isolates of C minitans were tested for ability to inhibit a number of filamentous fungi, yeasts, oomycetes and bacteria in agar based tests. Activity was found against some ascomycetes, basidiomycetes, oomycetes and Gram-positive bacteria, but not against zygomycetes, yeasts or Gram-negative bacteria tested. Six C. minitans isolates (Conio, Contans, IVT1, CM/AP/3118, B279/1, Al/327/1) were found to produce macrosphelide A in liquid culture and no other antibiotics were detected. On agar, macrosphelide A inhibited growth of some ascomycetes, basidiomycetes, oomycetes and all four Gram-positive bacteria tested, including the medically important Staphylococcus aureus with a minimum inhibitory concentration of <= 500 mu g ml(-1). There was no inhibition observed against the yeasts and Gram-negative bacteria when macrosphelide A was tested at 700 mu g ml(-1). Conclusions: The spectrum and level of activity of macrosphelide A produced by C. minitans against micro-organisms are extended markedly compared to previous reports. Significance and Impact of the Study: Macrosphelide A was effective against Staph. aureus. Further study on the control of this bacterium is merited in view of the development of antibiotic resistance.
| Item Type: | Journal Article |
|---|---|
| Subjects: | T Technology > TP Chemical technology Q Science > QR Microbiology |
| Journal or Publication Title: | Journal of Applied Microbiology |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 1364-5072 |
| Date: | June 2009 |
| Volume: | Vol.106 |
| Number: | No.6 |
| Number of Pages: | 9 |
| Page Range: | pp. 2048-2056 |
| Identification Number: | 10.1111/j.1365-2672.2009.04174.x |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/27845 |
Data sourced from Thomson Reuters' Web of Knowledge
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