Williams, Jonathan P., Bugarcic, Tijana, Habtemariam, Abraha, Giles, K. (Kevin), Campuzano, Iain, Rodger, P. Mark and Sadler, P. J.. (2009) Isomer separation and gas-phase configurations of organoruthenium anticancer complexes : ion mobility mass spectrometry and modeling. Journal of The American Society for Mass Spectrometry, Vol.20 (No.6). pp. 1119-1122. ISSN 1044-0305

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Abstract

We have used ion mobility-mass spectrometry combined with molecular modeling for the separation and configurational analysis of three low-molecular-weight isomeric organoruthenium anticancer complexes containing ortho-, meta-, or para-terphenyl arene ligands. The isomers were separated using ion mobility based on traveling-wave technology and the experimentally determined collision cross sections were compared to theoretical calculations. Excellent agreement was observed between the experimentally and theoretically derived measurements. (J Am Soc Mass Spectrom 2009, 20, 1119-1122) (C) 2009 American Society for Mass Spectrometry

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QC Physics
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Organoruthenium compounds -- Therapeutic use, Organometallic chemistry, Antineoplastic agents, Mass spectrometry, Ion mobility spectroscopy, DNA adducts, Isomers
Journal or Publication Title:	Journal of The American Society for Mass Spectrometry
Publisher:	Springer New York LLC
ISSN:	1044-0305
Date:	June 2009
Volume:	Vol.20
Number:	No.6
Number of Pages:	4
Page Range:	pp. 1119-1122
Identification Number:	10.1016/j.jasms.2009.02.016
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Warwick Research Development Fund
URI:	http://wrap.warwick.ac.uk/id/eprint/27893

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