Dissecting regulatory networks in host-pathogen interaction using ChIP-on-chip technology
Sala, Claudia, Grainger, David C. and Cole, Stewart T.. (2009) Dissecting regulatory networks in host-pathogen interaction using ChIP-on-chip technology. Cell Host & Microbe, Vol.5 (No.5). pp. 430-437. ISSN 1931-3128Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.chom.2009.04.007
Understanding host-microbe interactions has been greatly enhanced by our broadening knowledge of the regulatory mechanisms at the heart of pathogenesis. The "transcriptomics" approach of measuring global gene expression has identified genes involved in bacterial pathogenesis. More recently, chromatin immunoprecipitation (ChIP) and hybridization to microarrays (chIP-on-chip) has emerged as a complementary tool that permits protein-DNA interactions to be studied in vivo. Thus, chIP-on-chip can be used to map the binding sites of transcription factors, thereby teasing apart gene regulatory networks. In this Review, we discuss the ChIP-on-chip technique and focus on its application to the study of host-pathogen interactions.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology|
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)|
|Journal or Publication Title:||Cell Host & Microbe|
|Date:||21 May 2009|
|Number of Pages:||8|
|Page Range:||pp. 430-437|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||European Commission (LHSP-CT-2005-018923 and HEALTH-F3-2007-201762)|
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