Groom, Harriet C. T., Anderson, Emma C., Dangerfield, John A. and Lever, Andrew M. L.. (2009) Rev regulates translation of human immunodeficiency virus type 1 RNAs. Journal of General Virology, Vol.90 (Part 5). pp. 1141-1147. ISSN 0022-1317

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Abstract

Full-length human immunodeficiency virus type 1 (HIV-1) RNA acts as both mRNA, encoding Gag and Gag-Pol polyproteins, and genomic RNA. Translation of this RNA must be tightly controlled to allow sufficient protein synthesis prior to a switch to particle production. The viral protein Rev stimulates nuclear export of unspliced HIV-1 RNAs containing the Rev response element, but may also stimulate translation of these RNAs. We previously identified an additional Rev binding site in the 5' untranslated region of the HIV-1 RNA. We show that Rev inhibits translation non-specifically at high concentrations and stimulates translation of HIV-1 RNAs at intermediate concentrations in vitro. Stimulation is dependent on the presence of the Rev binding site within the 5' untranslated region and not on the Rev response element. In COS-1 cells, translation from an HIV-1 reporter is specifically increased by coexpression of Rev.

Item Type:	Journal Article
Subjects:	T Technology > TP Chemical technology Q Science > QR Microbiology > QR355 Virology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title:	Journal of General Virology
Publisher:	Society for General Microbiology
ISSN:	0022-1317
Date:	May 2009
Volume:	Vol.90
Number:	Part 5
Number of Pages:	7
Page Range:	pp. 1141-1147
Identification Number:	10.1099/vir.0.007963-0
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biomedical Research Centre, Sykes Trust
URI:	http://wrap.warwick.ac.uk/id/eprint/27975

Data sourced from Thomson Reuters' Web of Knowledge

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