Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Controlled delivery of antimicrobial gallium ions from phosphate-based glasses

Tools
- Tools
+ Tools

Valappil, S. P., Ready, D., Abou Neel, E. A., Pickup, D. M., O'Dell, L. A., Chrzanowski, W., Pratten, J., Newport, R. J., Smith, Mark E., Wilson, M. and Knowles, J. C. (2009) Controlled delivery of antimicrobial gallium ions from phosphate-based glasses. Acta Biomaterialia, Vol.5 (No.4). pp. 1198-1210. doi:10.1016/j.actbio.2008.09.019

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1016/j.actbio.2008.09.019

Request Changes to record.

Abstract

Gallium-doped phosphate-based glasses (PBGs) have been recently shown to have antibacterial activity. However, the delivery of gallium ions from these glasses can be improved by altering the calcium ion concentration to control the degradation rate of the glasses. In the present study, the effect of increasing calcium content in novel gallium (Ga2O3)-doped PBGs on the susceptibility of Pseudomonas aeruginosa is examined. The lack of new antibiotics in development makes gallium-doped PBG potentially a highly promising new therapeutic agent. The results show that an increase in calcium content (14, 15 and 16 mol.% CaO) cause a decrease in degradation rate (17.6, 13.5 and 7.3 mu g mm(-2) h(-1)), gallium ion release and antimicrobial activity against planktonic P. aeruginosa. The most potent glass composition (containing 14 mol.% CaO) was then evaluated for its ability to prevent the growth of biofilms of P. aeruginosa. Gallium release was found to reduce biofilm growth of P. aeruginosa with a maximum effect (0.86 log(10) CFU reduction compared to Ga2O3-free glasses) after 48 h. Analysis of the biofilms by confocal microscopy confirmed the anti-biofilm effect of these glasses as it showed both viable and non-viable bacteria on the glass surface. Results of the solubility and ion release studies show that this glass system is suitable for controlled delivery of Ga3+. Ga-71 NMR and Ga K-edge XANES measurements indicate that the gallium is octahedrally coordinated by oxygen atoms in all samples. The results presented here suggest that PBGs may be useful in controlled drug delivery applications, to deliver gallium ions in order to prevent infections due to P. aeruginosa biofilms. Crown Copyright (C) 2008 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. All rights reserved.

Item Type: Journal Article
Subjects: R Medicine
Divisions: Faculty of Science > Physics
Journal or Publication Title: Acta Biomaterialia
Publisher: Elsevier Science Ltd.
ISSN: 1742-7061
Official Date: May 2009
Dates:
DateEvent
May 2009Published
Volume: Vol.5
Number: No.4
Number of Pages: 13
Page Range: pp. 1198-1210
DOI: 10.1016/j.actbio.2008.09.019
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Engineering and Physical Sciences Research Council (EPSRC), University of Warwick
Grant number: GR/T21080/01, EP/C000714/1 (EPSRC), EP/C000633/1 (EPSRC)

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us