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Regulation of carboxylesterase 1 (CES1) in human adipose tissue

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Jernas, Margareta, Olsson, Bob, Arner, Peter, Jacobson, Peter, Sjostrom, Lars, Walley, Andrew, Froguel, Philippe, McTernan, P. G. (Philip G.), Hoffstedt, Johan and Carlsson, Lena M. S. (2009) Regulation of carboxylesterase 1 (CES1) in human adipose tissue. Biochemical and Biophysical Research Communications, Vol.383 (No.1). pp. 63-67. doi:10.1016/j.bbrc.2009.03.120

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Official URL: http://dx.doi.org/10.1016/j.bbrc.2009.03.120

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Abstract

Carboxylesterase 1 (CES1) has recently been suggested to play a role in lipolysis. Our aim was to Study the regulation of CES1 expression in human adipose tissue. In the SOS Sib Pair Study, CES1 expression was higher in obese compared with lean sisters (n = 78 pairs, P = 8.7 x 10(-18)) and brothers (n = 12 Pairs, P = 0.048). CES1 expression was higher in subcutaneous compared with omental adipose tissue in lean (P = 0.027) and obese Subjects (P = 0.00036), and reduced during diet-induced weight loss (it = 24, weeks 8, 16, and 18 compared to baseline, P < 0.0001 for all time points). CES1 expression was higher in isolated adipocytes compared with intact adipose tissue (P = 0.0018) and higher in large compared with small adipocytes (P = 4.1 x 10(-6)). Basal and Stimulated lipolysis was not different in individuals with high, intermediate, and low expression of CES1. Thus, CES1 expression was linked to body fat and adipocyte fat content but not to lipolytic activity. (C) 2009 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Biochemical and Biophysical Research Communications
Publisher: Elsevier
ISSN: 0006-291X
Official Date: 22 May 2009
Dates:
DateEvent
22 May 2009Published
Volume: Vol.383
Number: No.1
Number of Pages: 5
Page Range: pp. 63-67
DOI: 10.1016/j.bbrc.2009.03.120
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Royal Society (Great Britain), Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Diabetes Foundation, Dr. P. Hakanssons Foundation, Swedish Federal Government, Royal Physiographic Society (Nilsson-Ehle Foundation), Foundations of the National Board of Health and Welfare, Ake Wiberg Foundation, Torsten and Ragnar Soderberg Foundation, Arosenius Foundation, Jeansson Foundations, Tore Nilsson Foundation for Medical Research, Magnus Bergvall Foundation, Wellcome Trust
Grant number: K2007-55X11285-13-3, K2009-65X-15424-05, GR079534

Data sourced from Thomson Reuters' Web of Knowledge

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