Molostvov, G., Bland, Rosemary and Zehnder, Daniel (2009) Expression and role of the calcium-sensing receptor in the blood vessel wall. Current Pharmaceutical Biotechnology, Vol.10 (No.3). pp. 282-288. ISSN 1389-2010

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Abstract

The calcium-sensing receptor (CaSR), which is involved in systemic calcium homeostasis, has also been found to be functionally expressed on cells of the vascular wall. Its activation on perivascular nerves and endothelial cells has been shown to regulate arterial tone, peripheral vascular resistance and possibly local tissue perfusion. The expression of the CaSR on immune cells involved in vascular inflammation, such as macrophages, and its increased expression in inflammation indicates the central role extracellular calcium plays in vascular inflammation and repair. Further detailed analysis will clarify the role the vascular CaSR plays as a therapeutic target for complex disease conditions such as hypertension, tissue hypoperfusion, atherosclerosis and vascular calcification.

Item Type:	Journal Item
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Current Pharmaceutical Biotechnology
Publisher:	Bentham Science Publishers Ltd.
ISSN:	1389-2010
Date:	April 2009
Volume:	Vol.10
Number:	No.3
Number of Pages:	7
Page Range:	pp. 282-288
Identification Number:	10.2174/138920109787847466
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/28068

Data sourced from Thomson Reuters' Web of Knowledge

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